CAJ | 학술논문

目的观察大剂量单次给予甲巯咪唑及小剂量多次给予甲巯咪唑治疗Graves病的疗效及安全性,并研究两种剂量对于促甲状腺激素受体抗体(TRAb)的影响.方法 80例来我院就诊的患者均签署治疗知情同意书,将其随机均分为两组,A组为大剂量单次组(15 mg/次,1次/d),B组为小剂量多次组(10 mg/次,3次/d).治疗3个月后观察各组临床疗效、甲状腺激素、TRAb水平变化及副反应情况.结果治疗3月后,两组激素水平、临床疗效及TRAb水平均低于治疗前(P＜0.05),两组之间临床疗效及TRAb水平差异无统计学意义(P＞0.05),A组副反应,如皮疹、肝功损害、药物性甲减及粒细胞减少等,较B组明显下降(P＜0.05).结论大剂量单次给予甲巯咪唑可有效治疗Graves病,且相对于小剂量多次给药可减少副反应的发生.
목적 관찰대제량단차급여갑구미서급소제량다차급여갑구미서치료Graves병적료효급안전성,병연구량충제량대우촉갑상선격소수체항체(TRAb)적영향.방법 80례래아원취진적환자균첨서치료지정동의서,장기수궤균분위량조,A조위대제량단차조(15 mg/차,1차/d),B조위소제량다차조(10 mg/차,3차/d).치료3개월후관찰각조림상료효、갑상선격소、TRAb수평변화급부반응정황.결과 치료3월후,량조격소수평、림상료효급TRAb수평균저우치료전(P＜0.05),량조지간림상료효급TRAb수평차이무통계학의의(P＞0.05),A조부반응,여피진、간공손해、약물성갑감급립세포감소등,교B조명현하강(P＜0.05).결론 대제량단차급여갑구미서가유효치료Graves병,차상대우소제량다차급약가감소부반응적발생.
Objective To observe the efficacies and safety of methimazole with a single large dose or repeated small doses of administration in the treatment of Graves' disease and study the impact of the 2 methods on thyrotropin receptor antibody (TRAb).Methods 80 patients all signed informed consent and then were randomly divided into group A and B.Group A was single large dose group (15 mg/times,1 times/d);group B was multiple small dose group (10 mg/time,3 times/d).The clinical efficacy,hormone levels,TRAb levels,and side effects were observed after 3 months' treatment.Results After 3 months' treatment,the hormone levels,clinical efficacy,and TRAb levels were markedly lower than that before the treatment in both groups(P ＜ 0.05); there was no statistical difference in clinical efficacy and TRAb level between the two groups (P ＞ 0.05); but fewer patients occurred side effects (such as rash,liver damage,drug-induced hypothyroidism,and neutropenia) in group A than in group B(P ＜ 0.05).Conclusions Single large dose of methimazole is effective in the treatment of Graves' disease and has fewer side effects than repeated small dose.