中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
13期
1967-1968
,共2页
鼻炎,变应性,常年性%泼尼松龙%鼻甲%投药,鼻内
鼻炎,變應性,常年性%潑尼鬆龍%鼻甲%投藥,鼻內
비염,변응성,상년성%발니송룡%비갑%투약,비내
Rhinitis%allergic%perennial%Prednisolone%Turbinates%Administration%intranasal
目的 探讨下鼻甲注射泼尼松龙对常年性变应性鼻炎(PAR)治疗机制.方法 采用ELISA法测定及化学发光法检测下鼻甲注射泼尼松龙组(治疗组)、氯雷他定组(对照组)及查体健康组(健康组)的IL-4、IL-5、IgE的变化情况.结果 两组治疗前血清IL-4、IL-5、IgE水平明显升高,与健康组差异有统计学意义(P＜0.01),治疗后治疗组血清1L-4浓度为(62.76±18.21) ng/L、IL-5浓度为(24.32±9.47) ng/L、IgE浓度为(112.4±57.8) mg/L,与治疗前比较,差异有统计学意义(P＜0.05)；对照组治疗后血浆IL-4浓度为(140.18±25.78) ng/L,IL-5浓度为(60.17±17.28)ng/L,IgE浓度为(186.2 ±55.3)mg/L,与治疗前比较,差异无统计学意义(P＞0.05).结论 PAR患者的血清IL-4、IL-5、IgE水平明显高于健康组.下鼻甲注射泼尼松龙通过降低PAR患者的IL-4、IL-5、IgE水平而有效地治疗PAR.
目的 探討下鼻甲註射潑尼鬆龍對常年性變應性鼻炎(PAR)治療機製.方法 採用ELISA法測定及化學髮光法檢測下鼻甲註射潑尼鬆龍組(治療組)、氯雷他定組(對照組)及查體健康組(健康組)的IL-4、IL-5、IgE的變化情況.結果 兩組治療前血清IL-4、IL-5、IgE水平明顯升高,與健康組差異有統計學意義(P＜0.01),治療後治療組血清1L-4濃度為(62.76±18.21) ng/L、IL-5濃度為(24.32±9.47) ng/L、IgE濃度為(112.4±57.8) mg/L,與治療前比較,差異有統計學意義(P＜0.05)；對照組治療後血漿IL-4濃度為(140.18±25.78) ng/L,IL-5濃度為(60.17±17.28)ng/L,IgE濃度為(186.2 ±55.3)mg/L,與治療前比較,差異無統計學意義(P＞0.05).結論 PAR患者的血清IL-4、IL-5、IgE水平明顯高于健康組.下鼻甲註射潑尼鬆龍通過降低PAR患者的IL-4、IL-5、IgE水平而有效地治療PAR.
목적 탐토하비갑주사발니송룡대상년성변응성비염(PAR)치료궤제.방법 채용ELISA법측정급화학발광법검측하비갑주사발니송룡조(치료조)、록뢰타정조(대조조)급사체건강조(건강조)적IL-4、IL-5、IgE적변화정황.결과 량조치료전혈청IL-4、IL-5、IgE수평명현승고,여건강조차이유통계학의의(P＜0.01),치료후치료조혈청1L-4농도위(62.76±18.21) ng/L、IL-5농도위(24.32±9.47) ng/L、IgE농도위(112.4±57.8) mg/L,여치료전비교,차이유통계학의의(P＜0.05)；대조조치료후혈장IL-4농도위(140.18±25.78) ng/L,IL-5농도위(60.17±17.28)ng/L,IgE농도위(186.2 ±55.3)mg/L,여치료전비교,차이무통계학의의(P＞0.05).결론 PAR환자적혈청IL-4、IL-5、IgE수평명현고우건강조.하비갑주사발니송룡통과강저PAR환자적IL-4、IL-5、IgE수평이유효지치료PAR.
Objective To explore the treatment mechanism of inferior turbinate injection of prednisolone on perennial allergic rhinitis(PAR).Methods ELISA and chemiluminescence were used to detect the changes of IL-4,IL-5,IgE in inferior turbinate injection of prednisolone group (treatment group),loratadine group(control group) and healthy group(normal group).Results Compared with the normal group,serum IL-4,IL-5,IgE of 2 groups before treatment were significantly increased (P ＜ 0.01).After treatment,the serum IL-4 level of the treatment group was (62.76 ± 18.21) ng/L,IL-5 level was (24.32 ±9.47) ng/L,IgE level was (112.4 ±57.8) mg/L,compared with before treatment,the differences were statistically significant(P ＜ 0.05).After treatment,IL-4 level of the control group was (140.18 ±25.78) ng/L,IL-5 level was (60.17 ± 17.28) ng/L,IgE level was (186.2 ±55.3) mg/L,compared with before treatment,the differences were not statistically significant(P ＞ 0.05).Conclusions The serum IL-4,IL-5,IgE levels of PAR patients were higher than normal group.Inferior turbinate injection of prednisolone could decrease the IL-4,IL-5,IgE levels and effectively treat PAR.
