CAJ | 학술논문

目的探讨急性脑梗死患者血清P选择素和C反应蛋白(CRP)的动态变化及其临床意义.方法根据神经功能缺损程度评分将患者分为轻型组(38例)、中型组(35例)和重型组(25例),选取30例健康体检者为对照组,测定不同时间P选择素和CRP水平.结果轻型组、中型组、重型组入院24hP选择素水平均高于对照组,差异均有统计学意义(P＜0.05).轻型组、中型组、重型组入院3dP选择素水平均达到最高后逐渐下降;轻型组入院24 h、7dP选择素水平与中型组和重型组比较差异均有统计学意义(P＜0.05).轻型组、中型组、重型组入院3dP选择素水平三组间比较差异均有统计学意义(P＜ 0.05).轻型组、中型组入院14dP选择素水平与重型组比较差异均有统计学意义(P＜0.05).轻型组、中型组、重型组入院24 h CRP水平均高于对照组,差异均有统计学意义(P＜0.05).轻型组、中型组、重型组入院24 h、3d、7d、14 d CRP水平逐渐降低,三组间同时间点比较差异均有统计学意义(P＜0.05).直线相关分析显示P选择素水平与CRP水平呈正相关(r=0.493,P＜0.05).结论 P选择素与CRP可能参与脑梗死的病理过程,脑梗死患者时间、病变程度不同,P选择素和CRP的水平不同,测定它们有利于脑梗死的早期诊治及判断预后.
목적 탐토급성뇌경사환자혈청P선택소화C반응단백(CRP)적동태변화급기림상의의.방법 근거신경공능결손정도평분장환자분위경형조(38례)、중형조(35례)화중형조(25례),선취30례건강체검자위대조조,측정불동시간P선택소화CRP수평.결과 경형조、중형조、중형조입원24hP선택소수평균고우대조조,차이균유통계학의의(P＜0.05).경형조、중형조、중형조입원3dP선택소수평균체도최고후축점하강;경형조입원24 h、7dP선택소수평여중형조화중형조비교차이균유통계학의의(P＜0.05).경형조、중형조、중형조입원3dP선택소수평삼조간비교차이균유통계학의의(P＜ 0.05).경형조、중형조입원14dP선택소수평여중형조비교차이균유통계학의의(P＜0.05).경형조、중형조、중형조입원24 h CRP수평균고우대조조,차이균유통계학의의(P＜0.05).경형조、중형조、중형조입원24 h、3d、7d、14 d CRP수평축점강저,삼조간동시간점비교차이균유통계학의의(P＜0.05).직선상관분석현시P선택소수평여CRP수평정정상관(r=0.493,P＜0.05).결론 P선택소여CRP가능삼여뇌경사적병리과정,뇌경사환자시간、병변정도불동,P선택소화CRP적수평불동,측정타문유리우뇌경사적조기진치급판단예후.
Objective To evaluate and explore the Patients with acute cerebral infarction P-selectin and C-reactive protein (CRP) clinical significance.Methods According to the degree of neurological deficit scores were divided into light group (38 cases),medium group (35 cases) and severe group (25 cases),30healthy subjects were selected as the control group,measured at different time levels of P-selectin and CRP.Results Light group,medium group,severe group admitted 24 h P-selectin levels were higher,the difference was statistically significant (P ＜ 0.05).Light group,medium group,severe group admission decreased after 3 d P-selectin levels were highest; mild group admitted 24 h,7 d P-selectin levels and medium-sized group and severe group differences were statistically significant (P ＜ 0.05).Light group,medium group,severe group admission 3 d P-selectin levels were statistically significant differences (P ＜ 0.05) among the three groups.Light group,medium group admitted 14 d P-selectin levels and heavy group differences were statistically significant (P ＜ 0.05).Light group,medium group,severe group admitted 24 h CRP levels were higher,the difference was statistically significant (P ＜ 0.05).Light group,medium group,severe group admitted 24 h,3 d,7 d,14 d CRP levels decreased,comparing the differences among the three groups were statistically significant (P ＜ 0.05) at the same time point.Linear correlation analysis showed that P-selectin hormone levels and CRP levels were positively correlated (r =0.493,P ＜ 0.05).Conclusions Serum P-selectin and C reactive protein may be involved in the pathological process of ACI.The changes of serum P-selectin and C reactive protein levels were contributed to judge severity of pathological changes,focus range and prognosis assessment.It is an important biochemical observational indicator,and it's worthy recommending in clinic.