CAJ | 학술논문

糖尿病在全世界发病率普遍增高,糖尿病可引起干眼、角膜病、糖尿病视网膜病变、青光眼、白内障、屈光异常改变等一系列眼部并发症,严重影响视力甚至失明.近些年糖尿病对眼表造成损害正逐渐引起临床医师关注,糖尿病相关干眼主要表现为角膜上皮反复剥脱、上皮再生延迟、角膜敏感性下降等,这主要与糖尿病条件下泪液异常、泪液渗透压升高、泪膜稳定性差、角膜神经退行性改变等异常有关.现将糖尿病相关干眼的主要临床特点结合泪液变化、角膜神经敏感性变化、血糖水平、病程、降糖药物等相关影响因素以及特殊诊断方法和治疗策略等方面的进展进行总结,为临床诊断和治疗提供理论依据.
당뇨병재전세계발병솔보편증고,당뇨병가인기간안、각막병、당뇨병시망막병변、청광안、백내장、굴광이상개변등일계렬안부병발증,엄중영향시력심지실명.근사년당뇨병대안표조성손해정축점인기림상의사관주,당뇨병상관간안주요표현위각막상피반복박탈、상피재생연지、각막민감성하강등,저주요여당뇨병조건하루액이상、루액삼투압승고、루막은정성차、각막신경퇴행성개변등이상유관.현장당뇨병상관간안적주요림상특점결합루액변화、각막신경민감성변화、혈당수평、병정、강당약물등상관영향인소이급특수진단방법화치료책략등방면적진전진행총결,위림상진단화치료제공이론의거.
The incidence of diabetes mellitus has generally increased all over the world.Diabetes mellitus causes several complications,including dry eye,diabetic keratopathy,diabetic retinopathy,glaucoma,cataract,and ametropia,which seriously decrease visual acuity and even cause blindness.The correlation of diabetes mellitus and ocular surface complications is significantly elevated.Dry eye in diabetes mellitus mainly exhibits several clinical features that include recurring corneal epithelial exfoliation,the delay of corneal epithelial regeneration,and a decrease in corneal sensitivity.These anomolies are mainly caused by changes in tears,increasing tear film osmolarity,unstable tear film,and corneal nerve damage in hyperglycemic conditions.This paper briefly reviews research on the factors that influence dry eye in diabetes mellitus along with clinical features,and discusses new detection methods and treatment strategies.