CAJ | 학술논문

背景瑞芬太尼是一种新型的阿片受体激动剂,具有独特的快速起效和快速清除的优点,是麻醉过程中常用的镇痛药物.近来,发现瑞芬太尼对重要器官的缺血/再灌注损伤(ischemia/reperfusion injury,I/RI)具有保护作用. 目的回顾瑞芬太尼的基本理化特点及药代学特点,并讨论其对I/RI的保护作用和可能的作用机制. 内容大量研究表明瑞芬太尼对心脏、肝脏、神经系统和肾脏的I/RI均有保护作用.其作用机制尚未明了,可能与阿片受体、蛋白激酶C与ATP敏感性钾离子通道、一氧化氮与一氧化氮合酶、抗凋亡通道等有关. 趋向瑞芬太尼对于I/RI的保护作用,将进一步增加其临床应用价值,也为围术期器官保护提供新的思路.
배경 서분태니시일충신형적아편수체격동제,구유독특적쾌속기효화쾌속청제적우점,시마취과정중상용적진통약물.근래,발현서분태니대중요기관적결혈/재관주손상(ischemia/reperfusion injury,I/RI)구유보호작용. 목적 회고서분태니적기본이화특점급약대학특점,병토론기대I/RI적보호작용화가능적작용궤제. 내용 대량연구표명서분태니대심장、간장、신경계통화신장적I/RI균유보호작용.기작용궤제상미명료,가능여아편수체、단백격매C여ATP민감성갑리자통도、일양화담여일양화담합매、항조망통도등유관. 추향 서분태니대우I/RI적보호작용,장진일보증가기림상응용개치,야위위술기기관보호제공신적사로.
Background Remifentanil is a novel,opioid receptor agonist which is commonly used during anesthesia procedure.Remifentanil has protective effects against ischemia-reperfusion injury (I/RI) in vital organs.Objective To review the chemical properties and the characteristics of its pharmacokinetics,the protective effects against I/RI and possible mechanisms.Content Many researches have reported that remifentanil protect against heart,liver,nerve and kidney I/RI in different animal models.The related mechanisms are far from clear.Opioid receptors,PKC/KATP channel,NO/NOS,and anti-apoptotic pathways are the most concerned in published articles.Trend Remifentanil maybe widely accepted as an effective drag for both perioperative analgesia and I/RI protection.