CAJ | 학술논문

目的评价舌下含服标准化粉尘螨变应原滴剂治疗儿童变应性鼻炎的疗效及安全性.方法采用前后对照,比较125例粉尘螨变应性鼻炎儿童患者在接受1年免疫治疗前、后的症状评分、药物评分,评价舌下免疫治疗的疗效;计算不良反应发生率,评价其安全性.结果免疫治疗1年后,125例患儿症状评分和药物评分较治疗前均明显减少(P＜O.01),有效率81.6%;其中6例(4.8%)出现局部不良反应,未出现严重全身不良反应.结论舌下含服标准化粉尘螨变应原滴剂是治疗尘螨引起的儿童变应性鼻炎的一种有效治疗方法,并具有较好的安全性.
목적 평개설하함복표준화분진만변응원적제치료인동변응성비염적료효급안전성.방법 채용전후대조,비교125례분진만변응성비염인동환자재접수1년면역치료전、후적증상평분、약물평분,평개설하면역치료적료효;계산불량반응발생솔,평개기안전성.결과 면역치료1년후,125례환인증상평분화약물평분교치료전균명현감소(P＜O.01),유효솔81.6%;기중6례(4.8%)출현국부불량반응,미출현엄중전신불량반응.결론 설하함복표준화분진만변응원적제시치료진만인기적인동변응성비염적일충유효치료방법,병구유교호적안전성.
Objective To evaluate the efficacy and safety of sublingual immunotherapy with standardized dermatophagoides farinae drops for allergic rhinitis in children. Methods The symptom scores and medication scores were compared in 125 pediatric patients with allergic rhinitis one year after sublingual immunotherapy. The efficacy of immunotherapy was assessed and the adverse reactions were noted to assess the safety of the therapy. Results As compared with the baselines, the symptom and medication scores were significantly lower in all the patients one year after treatment ( P＜ 0.01 ), with an effectiveness rate of 81.6%. Six patients developed local adverse reactions, but no severe systemic adverse reactions occurred. Conclusions Sublingual immunotherapy with standardized dermatophagoides farinae drops is safe and effective in treating pediatric patients with allergic rhinitis caused by dermatophagoides farinae.