CAJ | 학술논문

目的：探究术前血清癌胚抗原( CEA)水平与结直肠癌术后复发的关系。方法回顾性分析164例结直肠癌根治术治疗的患者，跟踪随访上述病例并分析相关临床病理学指标及术前CEA水平同复发的关系。结果 CEA升高组的术后复发率较高(54．9%)，与CEA正常组相比，差异有统计学意义(P<0．05)。多因素分析表明，术前血清CEA水平、肿瘤分期与结直肠癌术后复发率阳性相关(P=0．003).结论术前血清CEA水平是预测结直肠癌术后复发问题的独立指标，术前血清CEA水平对结直肠癌根治术患者的治疗计划是有指导意义的。
목적：탐구술전혈청암배항원( CEA)수평여결직장암술후복발적관계。방법회고성분석164례결직장암근치술치료적환자，근종수방상술병례병분석상관림상병이학지표급술전CEA수평동복발적관계。결과 CEA승고조적술후복발솔교고(54．9%)，여CEA정상조상비，차이유통계학의의(P<0．05)。다인소분석표명，술전혈청CEA수평、종류분기여결직장암술후복발솔양성상관(P=0．003).결론술전혈청CEA수평시예측결직장암술후복발문제적독립지표，술전혈청CEA수평대결직장암근치술환자적치료계화시유지도의의적。
Objective To evaluate the prognostic value of preoperative serum carcinoembryonic antigen ( CEA) level in patients with colorectal cancer. Methods This retrospective study included 164 colorectal cancer patients aged from 25 to 69 years, surgically treated between April 2006 and October 2009. Correlation between postoperative recurrence and clinic pathologi-cal features or preoperative serum CEA levels was analyzed. Results Comparing with the normal CEA group, postoperative recur-rence rate in elevated CEA group (54. 9%) increased significantly (P<0. 05). Multivariate analysis indicated that both preoper-ative serum CEA levels and tumor stage correlated positively to postoperative recurrence rate of colorectal cancer patients ( P =0. 003). Conclusion Preoperative serum CEA is a reliable predictor factor for recurrence in patients with colorectal cancer. CEA might be used in treatment planning in colorectal cancer patients undergoing curative resection.