中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
9期
1280-1281
,共2页
曾淑云%邓文彬%邱宇%曾洪杰
曾淑雲%鄧文彬%邱宇%曾洪傑
증숙운%산문빈%구우%증홍걸
尿酸%肌酐%尿素氮%尿微量白蛋白%肾功能
尿痠%肌酐%尿素氮%尿微量白蛋白%腎功能
뇨산%기항%뇨소담%뇨미량백단백%신공능
Uric acid%Creatinine%Urea nitrogen%Urinary microalbumin%Renal function
目的 探讨血尿酸与尿微量白蛋白及肾功能相关性.方法 选取2009年1至2012年10月于我院内科门诊就诊的185例血尿酸升高患者,为观察组；同期在我院体检中心健康体检血尿酸正常者52例为对照组,统计学分析血尿酸水平与尿微量白蛋白(MAU)、血肌酐、BUN之间的关系.结果 观察组MAU[(74±25)mg/L]、血肌酐[(84±18)μmol/L]、BUN[(5.3±1.9) mmol/L]均明显高于对照组[分别为(18±7)mg/L、(68±16)μnnol/L、(4.7±1.7) mmol/L],差异均有统计学意义(均P＜0.05)；回归分析MAU＞35 mg/L[比值比(OR) =1.788,95％置信区间(CI)为1.255～3.589;P=0.005],血肌酐＞74 μmol/L[OR=1.798,95％ CI为1.586 ～ 6.957;P=0.034],BUN＞ 4.8 mmol/L[OR=2.561,95％CI为1.562～5.654;P=0.042]是血尿酸水平升高的危险因素.观察组尿微量白蛋白、血肌酐、BUN均随病程延长而升高,病程1～10年者(60例)尿微量白蛋白、血肌酐、BUN分别为(52±11)mg/L、(72±15)μmol/L、(4.5±1.9) mmol/L;病程11～20年者(71例)分别为(75±15) mg/L、(85±18)μmol/L、(5.3±1.9)mmoL/L;病程21～28年者(54例)分别为(94±19) mg/L、(96±20) μmol/L、(6.2±1.9) mmol/L,不同时期同指标比较差异均有统计学意义(均P＜0.05).结论 血尿酸升高可导致肾功能损害,早期干预有助于防治高尿酸致肾损害的进一步发展,减少尿毒症的发生.
目的 探討血尿痠與尿微量白蛋白及腎功能相關性.方法 選取2009年1至2012年10月于我院內科門診就診的185例血尿痠升高患者,為觀察組；同期在我院體檢中心健康體檢血尿痠正常者52例為對照組,統計學分析血尿痠水平與尿微量白蛋白(MAU)、血肌酐、BUN之間的關繫.結果 觀察組MAU[(74±25)mg/L]、血肌酐[(84±18)μmol/L]、BUN[(5.3±1.9) mmol/L]均明顯高于對照組[分彆為(18±7)mg/L、(68±16)μnnol/L、(4.7±1.7) mmol/L],差異均有統計學意義(均P＜0.05)；迴歸分析MAU＞35 mg/L[比值比(OR) =1.788,95％置信區間(CI)為1.255～3.589;P=0.005],血肌酐＞74 μmol/L[OR=1.798,95％ CI為1.586 ～ 6.957;P=0.034],BUN＞ 4.8 mmol/L[OR=2.561,95％CI為1.562～5.654;P=0.042]是血尿痠水平升高的危險因素.觀察組尿微量白蛋白、血肌酐、BUN均隨病程延長而升高,病程1～10年者(60例)尿微量白蛋白、血肌酐、BUN分彆為(52±11)mg/L、(72±15)μmol/L、(4.5±1.9) mmol/L;病程11～20年者(71例)分彆為(75±15) mg/L、(85±18)μmol/L、(5.3±1.9)mmoL/L;病程21～28年者(54例)分彆為(94±19) mg/L、(96±20) μmol/L、(6.2±1.9) mmol/L,不同時期同指標比較差異均有統計學意義(均P＜0.05).結論 血尿痠升高可導緻腎功能損害,早期榦預有助于防治高尿痠緻腎損害的進一步髮展,減少尿毒癥的髮生.
목적 탐토혈뇨산여뇨미량백단백급신공능상관성.방법 선취2009년1지2012년10월우아원내과문진취진적185례혈뇨산승고환자,위관찰조；동기재아원체검중심건강체검혈뇨산정상자52례위대조조,통계학분석혈뇨산수평여뇨미량백단백(MAU)、혈기항、BUN지간적관계.결과 관찰조MAU[(74±25)mg/L]、혈기항[(84±18)μmol/L]、BUN[(5.3±1.9) mmol/L]균명현고우대조조[분별위(18±7)mg/L、(68±16)μnnol/L、(4.7±1.7) mmol/L],차이균유통계학의의(균P＜0.05)；회귀분석MAU＞35 mg/L[비치비(OR) =1.788,95％치신구간(CI)위1.255～3.589;P=0.005],혈기항＞74 μmol/L[OR=1.798,95％ CI위1.586 ～ 6.957;P=0.034],BUN＞ 4.8 mmol/L[OR=2.561,95％CI위1.562～5.654;P=0.042]시혈뇨산수평승고적위험인소.관찰조뇨미량백단백、혈기항、BUN균수병정연장이승고,병정1～10년자(60례)뇨미량백단백、혈기항、BUN분별위(52±11)mg/L、(72±15)μmol/L、(4.5±1.9) mmol/L;병정11～20년자(71례)분별위(75±15) mg/L、(85±18)μmol/L、(5.3±1.9)mmoL/L;병정21～28년자(54례)분별위(94±19) mg/L、(96±20) μmol/L、(6.2±1.9) mmol/L,불동시기동지표비교차이균유통계학의의(균P＜0.05).결론 혈뇨산승고가도치신공능손해,조기간예유조우방치고뇨산치신손해적진일보발전,감소뇨독증적발생.
Objective To observe the correlation among serum uric acid,urinary microalbumin and renal function.Methods One hundred and eighty-five patients from January 2009 to October 2012 with higher serum uric acid level were studied as observation group.Other fifty-two healthy physical examinees with normal serum uric acid in the same term were as the control group.The serum uric acid with urinary microalbumin,serum creatinine and blood urea nitrogen were observed.Results The urinary microalbumin (74 ± 25) mg/L,serum creatinine (84 ± 18) μmol/L and blood urea nitrogen (5.3 ± 1.9) mmol/L in observation group were significantly higher than those in control group[respectively (18 ±7) mg/L,(68 ± 16) μmol/L,(4.7± 1.7) mmol/L] (P ＜ 0.05).The elevation of serum uric acid level was positively related with the level of urinary microalbumin [odds ratio (OR) =1.788,95％ confidence intervals(CI):1.255-3.589 ;P =0.005),serum creatinine (OR =1.798,95％ CI:1.586-6.957 ;P =0.034) and blood urea nitrogen (OR =2.561,95 ％ CI:1.562-5.654 ;P =0.042) by regression analysis.The urinary microalbumin,serum creatinine and blood urea nitrogen of observation group were relatively (52 ±11) mg/L,(72 ± 15) μmol/L,(4.5 ± 1.9) mmol/L in 1-10 years course,(75 ± 15) mg/L,(85 ± 18) μmol/L,(5.3 ± 1.9) mmol/L in 11-20 years course and (94 ± 19) mg/L,(96 ± 20) μmol/L,(6.2 ± 1.9) mmol/L in 21-28 years couse of disease.The differences all had statistical significant (P ＜ 0.05).Conclusions Elevated serum uric acid can cause renal impairment.Early intervention prevents further development of renal damage caused by high uric acid and reduce the incidence of uremia.
