CAJ | 학술논문

目的：探讨慢性阻塞性肺病急性加重期( AECOPD)患者血清IL-32和CRP的含量变化及临床意义。方法分别检测33例AECOPD患者治疗前后及20例健康体检者外周血,采用双抗体 ELISA法测定 IL-32,免疫比浊法测定CRP。结果 AECOPD患者治疗前血清IL-32为(126．44±86．69) pg/mL,CRP水平为(40．8±21．1) mg/L,明显高于治疗后(均P<0.05)；且治疗前血清IL-32、CRP水平较正常对照组显著增高(P<0.05)；治疗后血清IL-32、CRP水平仍高于正常对照组(P<0．05)。结论动态监测血清IL-32、CRP变化对于评价AECOPD患者病情具有一定的临床意义。
목적：탐토만성조새성폐병급성가중기( AECOPD)환자혈청IL-32화CRP적함량변화급림상의의。방법분별검측33례AECOPD환자치료전후급20례건강체검자외주혈,채용쌍항체 ELISA법측정 IL-32,면역비탁법측정CRP。결과 AECOPD환자치료전혈청IL-32위(126．44±86．69) pg/mL,CRP수평위(40．8±21．1) mg/L,명현고우치료후(균P<0.05)；차치료전혈청IL-32、CRP수평교정상대조조현저증고(P<0.05)；치료후혈청IL-32、CRP수평잉고우정상대조조(P<0．05)。결론동태감측혈청IL-32、CRP변화대우평개AECOPD환자병정구유일정적림상의의。
Objective To study the implication of interleukin-32(IL-32)and C-reactive protein(CRP)in the exacerbation of chronic obstructive pulmonary diseases(AECOPD). Methods The serum was sampled and prepared from 33 cases of COPD patients with acute exacerbation before and after two weeks therapy and 20 normal controls. Serum level of IL-32 was detected by ELISA and CRP by immunoturbidimetry method. Results The level of IL-32 in AECOPD Is significantly higher than that after therapy(P<0. 05)and lower than that in control group(P<0. 05). The level of CRP in acute exacerbation is significantly higher than that in control group(P<0. 05). Conclusion IL-32 and CRP are involved in the acute inflammation in COPD which may be indices of infection in COPD patients.