世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2014年
3期
316-317,320
,共3页
类风湿性关节炎%阻络型%中药
類風濕性關節炎%阻絡型%中藥
류풍습성관절염%조락형%중약
Rheumatoid arthritis%Retention of dampness-heat in channel%Traditional Chinese medicine
目的：在辨病和辨证相结合的基础上，提出类风湿关节炎（ Rheumatoid Arthritis ，RA）的治疗原则，探讨不同中药联合治疗阻络型RA的疗效情况。方法：选取我院2010年12月至2012年12月收治的60例RA患者按照随机双盲对照试验设计方法将患者分为治疗组和对照组，每组30例。治疗组口服雷公藤多甙片和尪痹颗粒，对照组口服虎力散胶囊和复方风湿宁。比较治疗4周、8周后的临床疗效及治疗前、后关节的晨僵时间、压痛指数、肿胀指数、类风湿因子转阴情况及不良反应。结果：两组患者治疗4周、8周后，治疗组总有效率分别为83.3％、90.0％，对照组为80.0％和86.7％（ P＞0.05）；两组类风湿因子转阴率分别为76.7％和70.0％（P＞0.05）；且两组治疗前、后关节的晨僵时间、压痛指数、肿胀指数差别都不明显（P＞0.05）；而在不良反应方面，治疗组为6.67％，对照组为30.00％，两组比较，差异有统计学意义（P＜0.05）。结论：不同联合用药方式治疗阻络型类风湿关节炎的综合疗效差别不明显，但药物不良反应的发生有不同。
目的：在辨病和辨證相結閤的基礎上，提齣類風濕關節炎（ Rheumatoid Arthritis ，RA）的治療原則，探討不同中藥聯閤治療阻絡型RA的療效情況。方法：選取我院2010年12月至2012年12月收治的60例RA患者按照隨機雙盲對照試驗設計方法將患者分為治療組和對照組，每組30例。治療組口服雷公籐多甙片和尪痺顆粒，對照組口服虎力散膠囊和複方風濕寧。比較治療4週、8週後的臨床療效及治療前、後關節的晨僵時間、壓痛指數、腫脹指數、類風濕因子轉陰情況及不良反應。結果：兩組患者治療4週、8週後，治療組總有效率分彆為83.3％、90.0％，對照組為80.0％和86.7％（ P＞0.05）；兩組類風濕因子轉陰率分彆為76.7％和70.0％（P＞0.05）；且兩組治療前、後關節的晨僵時間、壓痛指數、腫脹指數差彆都不明顯（P＞0.05）；而在不良反應方麵，治療組為6.67％，對照組為30.00％，兩組比較，差異有統計學意義（P＜0.05）。結論：不同聯閤用藥方式治療阻絡型類風濕關節炎的綜閤療效差彆不明顯，但藥物不良反應的髮生有不同。
목적：재변병화변증상결합적기출상，제출류풍습관절염（ Rheumatoid Arthritis ，RA）적치료원칙，탐토불동중약연합치료조락형RA적료효정황。방법：선취아원2010년12월지2012년12월수치적60례RA환자안조수궤쌍맹대조시험설계방법장환자분위치료조화대조조，매조30례。치료조구복뢰공등다대편화왕비과립，대조조구복호력산효낭화복방풍습저。비교치료4주、8주후적림상료효급치료전、후관절적신강시간、압통지수、종창지수、류풍습인자전음정황급불량반응。결과：량조환자치료4주、8주후，치료조총유효솔분별위83.3％、90.0％，대조조위80.0％화86.7％（ P＞0.05）；량조류풍습인자전음솔분별위76.7％화70.0％（P＞0.05）；차량조치료전、후관절적신강시간、압통지수、종창지수차별도불명현（P＞0.05）；이재불량반응방면，치료조위6.67％，대조조위30.00％，량조비교，차이유통계학의의（P＜0.05）。결론：불동연합용약방식치료조락형류풍습관절염적종합료효차별불명현，단약물불량반응적발생유불동。
Objective:To assess clinical effectiveness and adverse effect of integrated application of TCM in treating Rheumatoid Arthri -tis( RA) of retention of dampness-heat in channel type .Methods: A total amount of 60 RA patients admitted in our hospital from De-cember 2010 to December 2012 were divided into observation group and control group according to a double-blind randomized controlled trial design method , with 30 cases in each group .Patients in the observation group were treated with Tripterygium Wilfordii and Wangbi granule , while control group applied oral hulisan capsule and compound fengshining .Comparison was made in terms of the clinical thera-peutic effect after 4 weeks and 8 weeks of treatment , the time of morning stiffness , joint pain index , swelling index , rheumatoid factor negative and adverse reaction before and after treatment .Results:After 4 and 8 weeks of treatment , the total effective rates of the obser-vation group were 83.3%and 90%, and those of the control group were 80% and 86.7%( P>0.05; the rheumatoid factor negative rate of the two groups were 76.7%and 70%(P>0.05);before and after treatment, the differences of morning stiff joints time , tender-ness index, swelling index were not obvious (P>0.05);the occurrence rate of adverse reactions in the observation group was 6.67%, while that in the control group was 30%, and there was a significant difference between the two groups ( P<0.05 ) .Conclusion: The comprehensive effect of applying different medication treatment of obstruction of collaterals type in rheumatoid arthritis is not obviously different, but the occurrence of complications is different .
