中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
2期
57-57,58
,共2页
抗环瓜氨酸抗体%类风湿关节炎%特异性%敏感性
抗環瓜氨痠抗體%類風濕關節炎%特異性%敏感性
항배과안산항체%류풍습관절염%특이성%민감성
Anti-CCP antibody%Rheumatoid arthritis%Specificity%Sensitivity
目的：探讨检测类风湿关节炎患者体内抗环瓜氨酸多肽(CCP)水平在病情诊断过程中的临床应用价值。方法：选取类风湿关节炎患者80例，其他类别结缔组织疾病患者80例以及同期接受体检的健康人群80例为研究对象，采用酶联免疫吸附法对三组血清中抗CCP抗体滴度进行检测，并检测类风湿关节炎患者、其他类别结缔疾病患者以及健康人群体内IgM-RF阳性表达率，并对类风湿关节炎诊断过程中抗CCP抗体的特异度进行计算。结果：与其他类别结缔疾病患者以及健康人群相比，类风湿性关节炎患者血清中抗CCP抗体阳性表达率明显更高，差异有统计学意义(P<0.05)；在本次80例健康体检人群中，78例抗CCP抗体检测为真阴性，余2例为假阳性，抗CCP抗体特异性为97.5%；健康体检人群中抗CCP抗体假阳性率2.5%，明显低于IgM-RF假阳性率21.3%，差异有统计学意义(P<0.05)。结论：在诊断类风湿关节炎过程中，抗CCP抗体特异度极高，其滴度与其他结缔组织疾病患者以及健康人群相比明显更高，具有较高的临床诊断价值。
目的：探討檢測類風濕關節炎患者體內抗環瓜氨痠多肽(CCP)水平在病情診斷過程中的臨床應用價值。方法：選取類風濕關節炎患者80例，其他類彆結締組織疾病患者80例以及同期接受體檢的健康人群80例為研究對象，採用酶聯免疫吸附法對三組血清中抗CCP抗體滴度進行檢測，併檢測類風濕關節炎患者、其他類彆結締疾病患者以及健康人群體內IgM-RF暘性錶達率，併對類風濕關節炎診斷過程中抗CCP抗體的特異度進行計算。結果：與其他類彆結締疾病患者以及健康人群相比，類風濕性關節炎患者血清中抗CCP抗體暘性錶達率明顯更高，差異有統計學意義(P<0.05)；在本次80例健康體檢人群中，78例抗CCP抗體檢測為真陰性，餘2例為假暘性，抗CCP抗體特異性為97.5%；健康體檢人群中抗CCP抗體假暘性率2.5%，明顯低于IgM-RF假暘性率21.3%，差異有統計學意義(P<0.05)。結論：在診斷類風濕關節炎過程中，抗CCP抗體特異度極高，其滴度與其他結締組織疾病患者以及健康人群相比明顯更高，具有較高的臨床診斷價值。
목적：탐토검측류풍습관절염환자체내항배과안산다태(CCP)수평재병정진단과정중적림상응용개치。방법：선취류풍습관절염환자80례，기타유별결체조직질병환자80례이급동기접수체검적건강인군80례위연구대상，채용매련면역흡부법대삼조혈청중항CCP항체적도진행검측，병검측류풍습관절염환자、기타유별결체질병환자이급건강인군체내IgM-RF양성표체솔，병대류풍습관절염진단과정중항CCP항체적특이도진행계산。결과：여기타유별결체질병환자이급건강인군상비，류풍습성관절염환자혈청중항CCP항체양성표체솔명현경고，차이유통계학의의(P<0.05)；재본차80례건강체검인군중，78례항CCP항체검측위진음성，여2례위가양성，항CCP항체특이성위97.5%；건강체검인군중항CCP항체가양성솔2.5%，명현저우IgM-RF가양성솔21.3%，차이유통계학의의(P<0.05)。결론：재진단류풍습관절염과정중，항CCP항체특이도겁고，기적도여기타결체조직질병환자이급건강인군상비명현경고，구유교고적림상진단개치。
Objective:To investigate the clinical application value of anti-cyclic levels in diagnosis of patients with rheumatoid arthritis.Method:Selected 80 patients with rheumatoid arthritis,80 patients with other kinds of connective tissue disease,and 80 cases of healthy people accepted medical examination at the same period for the study.Enzyme-linked immunosorbent method of three groups of serum anti CCP antibody were tested,and tested the IgM-RF positive expression rate of patients with rheumatoid arthritis and other category connective disease patients and healthy people,and calculated the CCP antibody specificity in the process of rheumatoid arthritis diagnosis.Result:Compared to patients with other kinds of connective tissue disease and cases of healthy people,the CCP antibody positive expression rate of rheumatoid arthritis patients was significantly higher(P<0.05);In 80 cases of healthy people,78 cases of anti CCP antibody testing was true negative,2 cases of false positives,anti-CCP antibodies specificity of 97.5%;The rate of false positives of healthy people was 2.5%,significantly lower than the IgM-RF false positive rate for 21.3%,the differences were statistically significant (P<0.05).Conclusion:In the process of diagnosis of rheumatoid arthritis,anti-CCP antibody specificity is extremely high,the titer in patients with other connective tissue diseases as well as a significantly higher compared to healthy subjects,with a high clinical value.
