CAJ | 학술논문

目的：探讨脑利钠肽( BNP)和钠离子( Na +)在儿童热性惊厥发病中的作用机制及临床意义。方法选择符合热性惊厥诊断标准的病例48例,其中复杂型热性惊厥组(CFC)20例,单纯型热性惊厥组(SFC)28例,上呼吸道感染组(URI)20例,对照组15例。测定血清BNP水平、Na +水平。各组检测指标通过统计分析比较其差异及相关关系。结果血清BNP和Na离子水平：CFC组BNP水平高于SFC组、URI组和对照组；CFC组Na +水平低于其他组,差异具有显著性(P<0．05)。其他各组之间两两比较差异无显著性(P>0．05)。 BNP与Na +之间具有负相关关系(相关系数 r=-0．54,P<0．01)。结论热性惊厥刺激BNP的分泌,高水平BNP抑制醛固酮系统,使血钠水平下降,降低惊厥阈值。从而发生热性惊厥和惊厥性脑损伤的发生。因此,测定热性惊厥患儿血清中的BNP和Na +水平对热性惊厥的发病机制、分型及预后判断可能具有重要的临床价值。
목적：탐토뇌리납태( BNP)화납리자( Na +)재인동열성량궐발병중적작용궤제급림상의의。방법선택부합열성량궐진단표준적병례48례,기중복잡형열성량궐조(CFC)20례,단순형열성량궐조(SFC)28례,상호흡도감염조(URI)20례,대조조15례。측정혈청BNP수평、Na +수평。각조검측지표통과통계분석비교기차이급상관관계。결과혈청BNP화Na리자수평：CFC조BNP수평고우SFC조、URI조화대조조；CFC조Na +수평저우기타조,차이구유현저성(P<0．05)。기타각조지간량량비교차이무현저성(P>0．05)。 BNP여Na +지간구유부상관관계(상관계수 r=-0．54,P<0．01)。결론열성량궐자격BNP적분비,고수평BNP억제철고동계통,사혈납수평하강,강저량궐역치。종이발생열성량궐화량궐성뇌손상적발생。인차,측정열성량궐환인혈청중적BNP화Na +수평대열성량궐적발병궤제、분형급예후판단가능구유중요적림상개치。
Objective To investigate the pathogenesis and clinical significance of BNP and sodium ion in children with febrile convulsion. Methods Forty-eight children with febrile convulsion were enrolled in this study,Including 20 case of complex febrile convulsion(CFC group) ,28 case of simple febrile convulsion(SFC group),20 case of upper respiratory tract infection ( URI group) and 15 health children as the control group were enrolled in this study. the serum levels of BNP were determined by radioimmunoassay, the serum levels of Na + was measured by Full Automatic biochemical analyzer. The statistical analysis was used to compare the difference of each group. Results The serum BNP and NA + levels:BNP level of CFC group was higher than the SFC group,URI group and control group (P<0. 05),and NA + level of CFC group was lower than the other three groups (P<0. 05). There was no statistical difference among the other three groups (P>0. 05). BNP has the negative correlation with NA +(r= -0. 54,P<0. 01). Conclusion Fever convulsion can increase the secretion of BNP, high levels of BNP adjust the wa-ter-electrolyte metabolism,decrease the sodium ion level. Therefore,BNP combining with hyponatremias could induce the onset of convulsion and brain injured. BNP and sodium ion may play an important position in the onset of of febrile convulsion.