CAJ | 학술논문

白细胞介素22（IL-22）是白细胞介素10家族中的一员，与IL-10具有相似的结构和免疫作用，主要由Th22、Th1、Th17细胞、固有淋巴细胞（ILCs）、γδT细胞和NKT细胞分泌。IL-22在自身免疫性疾病、恶性肿瘤和感染性疾病中发挥重要作用。有关IL-22细胞因子在各种恶性肿瘤中的作用机制，仍是目前研究的热点。研究IL-22在恶性肿瘤中的表达及作用机制，为恶性肿瘤的治疗和预防提供了新的思路。本文从IL-22的发现、结构特点及其在恶性肿瘤中的作用进行综述。
백세포개소22（IL-22）시백세포개소10가족중적일원，여IL-10구유상사적결구화면역작용，주요유Th22、Th1、Th17세포、고유림파세포（ILCs）、γδT세포화NKT세포분비。IL-22재자신면역성질병、악성종류화감염성질병중발휘중요작용。유관IL-22세포인자재각충악성종류중적작용궤제，잉시목전연구적열점。연구IL-22재악성종류중적표체급작용궤제，위악성종류적치료화예방제공료신적사로。본문종IL-22적발현、결구특점급기재악성종류중적작용진행종술。
Interleukin-22 (IL-22) is a member of the IL-10 family, which exhibits a similar structure and immune function with IL-10. IL-22 is mainly secreted by Th22, Th1, and Th17 cells, innate lymphoid cells (ILCs), and γδT and NKT cells. IL-22 is mainly in-volved in autoimmune diseases, malignant tumors, and infective diseases. As such, studies have focused on the function of IL-22 cyto-kine in the pathogenesis of various malignant tumors. Studies revealing the expression and pathogenesis of IL-22 in malignant tumors possibly provide a new method to treat and prevent malignant tumors. In our study, the discovery, structural characteristics, and func-tions of IL-22 in malignant tumors are reviewed.