CAJ | 학술논문

总结近期国内外有关miRNA在乳腺癌化疗耐药中作用的研究进展。应用Pubmed和CNKI期刊全文数据库检索系统以“miRNA、乳腺癌和化疗耐药”为关键词，检索2000年1月至2012年10月有关在乳腺癌化疗耐药中作用的文献。从乳腺癌化疗耐药入手，阐述乳腺癌化疗耐药的特点、机制，并着重对miRNA在乳腺癌化疗耐药中的作用进行分析。miRNA通过多种途径参与乳腺癌的化疗耐药。本文具体综述了一些以不同机制参与肿瘤耐药的miRNA，及其具体参与耐药的途径。探讨了血清miRNA作为肿瘤标记物的潜在临床利用性。结论：深入研究血清miRNA在乳腺癌耐药中的作用和机制，必将为乳腺癌的靶向治疗掀起一个新的篇章。
총결근기국내외유관miRNA재유선암화료내약중작용적연구진전。응용Pubmed화CNKI기간전문수거고검색계통이“miRNA、유선암화화료내약”위관건사，검색2000년1월지2012년10월유관재유선암화료내약중작용적문헌。종유선암화료내약입수，천술유선암화료내약적특점、궤제，병착중대miRNA재유선암화료내약중적작용진행분석。miRNA통과다충도경삼여유선암적화료내약。본문구체종술료일사이불동궤제삼여종류내약적miRNA，급기구체삼여내약적도경。탐토료혈청miRNA작위종류표기물적잠재림상이용성。결론：심입연구혈청miRNA재유선암내약중적작용화궤제，필장위유선암적파향치료흔기일개신적편장。
This study aimed to review the research progress on the contribution of microRNA (miRNA) to the chemotherapy re-sistance of breast cancer. With“miRNA,”“breast cancer,”and“chemotherapy resistance”as key words, the literature was searched in Pubmed and CNKI databases between 01-2000 and 10-10-2012. We described the characteristics and mechanisms of breast cancer che-motherapy resistance and focused on the contribution of miRNAs in the chemotherapy resistance of breast cancer. MiRNA participate in chemotherapy resistance of breast cancer through different ways. This article summarizes different miRNAs that participate in che-motherapy resistance and identifies their specific pathways in drug resistance. The potential clinical utilization of the serum miRNA as a tumor marker is also discussed. Further research on the effect and mechanism of serum microRNA in chemotherapy resistance will bring a new chapter in the targeted therapy of breast cancer.