CAJ | 학술논문

肝细胞癌(HCC)肿瘤新生血管的生成在肿瘤的发生、进展及转移中起着重要的作用,肿瘤新生血管的结构与正常血管具有明显差异.免疫组化法测定微血管密度虽为评价肿瘤新生血管的“金标准”,但该方法是一项有创性的检查,其临床应用受到限制.多排螺旋CT、MRI、超声及核医学显像检查等无创的影像学检查方法以及数字减影血管造影等已广泛应用于临床上对HCC肿瘤新生血管的评价,可以为HCC的定性诊断提供依据.光学成像、同步辐射X射线成像等分子影像学方法也逐步应用于HCC肿瘤新生血管评价的动物实验研究中.
간세포암(HCC)종류신생혈관적생성재종류적발생、진전급전이중기착중요적작용,종류신생혈관적결구여정상혈관구유명현차이.면역조화법측정미혈관밀도수위평개종류신생혈관적“금표준”,단해방법시일항유창성적검사,기림상응용수도한제.다배라선CT、MRI、초성급핵의학현상검사등무창적영상학검사방법이급수자감영혈관조영등이엄범응용우림상상대HCC종류신생혈관적평개,가이위HCC적정성진단제공의거.광학성상、동보복사X사선성상등분자영상학방법야축보응용우HCC종류신생혈관평개적동물실험연구중.
Tumor neoangiogenesis plays an important role in growth and metastasis of human hepatocellular carcinoma (HCC).Angiogenesis induced by tumor cells is different from the normal vessels.Microvessel density measured by immunohistochemistry is used as the gold standard for assessment of angiogenesis,but it is an invasive diagnostic method and its clinical application is restricted.Digital subtraction angiography and noninvasive imaging examinations such as multi-slice spiral CT,MRI,ultrasound,nuclear medicine diagnosis are widely used in clinic for assessment of angiogenesis induced by tumor cells,which can play an important role in clinical diagnosis of HCC and assessment of the treatment effect of inhibiting angiogenesis induced by tumor cells.Molecular images such as optical imaging and synchrotron radiation X-ray imaging are gradually used in the experimental study of assessment of angiogenesis induced by tumor cells.