CAJ | 학술논문

目的：观察分析非结核分枝杆菌（NTM）的耐药情况。方法收集本院分枝杆菌培养阳性并鉴定为非结核分枝杆菌的病例，并对其药效结果进行分析。结果320例分枝杆菌培养阳性病例中，54例为非结核分枝杆菌，占16.9%，对二线抗结核药物阿米卡星（AK），卷曲霉素（CPM），对氨基水杨酸钠（PAS），莫西沙星（MFX），左氧氟沙星（LFX）和丙硫异烟胺（TH1321）均有不同程度的耐药，耐药率高达87.0%，且大多数呈现多耐药。结论非结核分枝杆菌对抗结核药呈现耐药现象，故临床用药困难，对临床抗结核治疗效果不佳或疑似NTM肺病的患者应及早做痰培养、菌型鉴定及药物敏感试验并寻求其他有效的治疗方法。
목적：관찰분석비결핵분지간균（NTM）적내약정황。방법수집본원분지간균배양양성병감정위비결핵분지간균적병례，병대기약효결과진행분석。결과320례분지간균배양양성병례중，54례위비결핵분지간균，점16.9%，대이선항결핵약물아미잡성（AK），권곡매소（CPM），대안기수양산납（PAS），막서사성（MFX），좌양불사성（LFX）화병류이연알（TH1321）균유불동정도적내약，내약솔고체87.0%，차대다수정현다내약。결론비결핵분지간균대항결핵약정현내약현상，고림상용약곤난，대림상항결핵치료효과불가혹의사NTM폐병적환자응급조주담배양、균형감정급약물민감시험병심구기타유효적치료방법。
Objective To evaluate the drug resistance actuality of nontuberculosis Mycobacteria (NTM). Methods Analysis was carried out on anti-tuberculosis (TB) drug efifcacy in the patients who were conifrmed to be Mycobacterial culture positive but not Mycobacterium tuberculosis cases. Results There were 54 cases of nontuberculosis Mycobacteria among 320 cases of Mycobacteria culture positive cases, accounting for 16.9%, exhibited different degrees of drug tolerance to second-line anti-TB drugs, such as amikacin (AK), capreomycin (CPM), sodium para-aminosalicylate (PAS), moxilfoxacin (MFX), levolfoxacin (LFX) and protionamide (TH1321), and most of which presented multidrug resistance. Conclusions Resistance of nontuberculosis Mycobacteria to anti-TB drug leads to the dififculties of clinical application. Sputum culture, bacteria identiifcation, drug sensitive test and other treatments should be adopted for patients with unacceptable clinical anti-TB treatment effects or patients with suspected NTM lung disease.