中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
1期
132-135
,共4页
Rac%p21活化激酶类%肿瘤%信号通路%结直肠肿瘤
Rac%p21活化激酶類%腫瘤%信號通路%結直腸腫瘤
Rac%p21활화격매류%종류%신호통로%결직장종류
Rac%p21-activated kinases%Neoplasm%Signaling pathway%Colorectal neoplasms
Rac 及其下游靶蛋白 p21活化激酶(PAK)均是最近新发现的多功能效应因子,与多种肿瘤的发生、发展密切相关。PAK主要通过其N端调节/黏附区的p21结合域(PBD)与上游调节器Rac相互作用从而使Rac/PAK信号通路激活,在结直肠癌的发生、发展、侵袭及转移中发挥重要的作用。随着研究的深入,越来越多的证据表明Rac/PAK信号通路不仅可以作为一种预测因子来判断结直肠癌的恶性进展及估计预后并且可能成为结直肠癌治疗的药物靶点,这些都为Rac/PAK信号通路应用于结直肠癌的诊疗提供了广阔的前景。
Rac 及其下遊靶蛋白 p21活化激酶(PAK)均是最近新髮現的多功能效應因子,與多種腫瘤的髮生、髮展密切相關。PAK主要通過其N耑調節/黏附區的p21結閤域(PBD)與上遊調節器Rac相互作用從而使Rac/PAK信號通路激活,在結直腸癌的髮生、髮展、侵襲及轉移中髮揮重要的作用。隨著研究的深入,越來越多的證據錶明Rac/PAK信號通路不僅可以作為一種預測因子來判斷結直腸癌的噁性進展及估計預後併且可能成為結直腸癌治療的藥物靶點,這些都為Rac/PAK信號通路應用于結直腸癌的診療提供瞭廣闊的前景。
Rac 급기하유파단백 p21활화격매(PAK)균시최근신발현적다공능효응인자,여다충종류적발생、발전밀절상관。PAK주요통과기N단조절/점부구적p21결합역(PBD)여상유조절기Rac상호작용종이사Rac/PAK신호통로격활,재결직장암적발생、발전、침습급전이중발휘중요적작용。수착연구적심입,월래월다적증거표명Rac/PAK신호통로불부가이작위일충예측인자래판단결직장암적악성진전급고계예후병차가능성위결직장암치료적약물파점,저사도위Rac/PAK신호통로응용우결직장암적진료제공료엄활적전경。
Rac and its downstream target proteins p-21 activated kinase (PAK) are multifunctional effector which were discovered recently, have close connection with the occurrence and progression of various neoplasms. Through p21-binding domain (PBD) which at N-terminal's regulate/adhesion area, PAK interacts with the upstream regulator Rac so that Rac/PAK signaling pathway activation. It plays an important role in the occurrence, development, invasion and metastasis of colorectal cancer. With the deepening of the research, more and more evidence suggests that Rac/PAK signaling pathway can not only be judged as a predictor for malignant progression and prognosis of colorectal cancer, but also become a drug target for treatment of colorectal cancer, which have provided a broad prospect for application of Rac/PAK signal pathway in diagnosis and treatment of colorectal cancer.