CAJ | 학술논문

目的：研究宿主p53基因密码子72多态性（Pro/Arg）在HPV16感染者和正常健康人群中的分布情况。方法采用 TaqMan SNP Genotyping Assays 方法进行 p53基因密码子72（Pro/Arg）多态性分析。结果 p53基因密码子72（Pro/Arg）突变的基因型和等位基因频率在HPV16感染组和对照组中差异无统计学意义（P＝0.30和P＝0.88）。不同遗传模型分析显示，p53基因密码子72（Pro/Arg）多态性在HPV16感染组和对照组中差异无统计学意义（P 0.12～0.88）。结论本研究未发现宿主p53基因密码子72（Pro/Arg）多态性与HPV16感染相关，结合其他报道数据，推测该突变可能在宫颈正常细胞向癌症细胞转化中起到重要作用。
목적：연구숙주p53기인밀마자72다태성（Pro/Arg）재HPV16감염자화정상건강인군중적분포정황。방법채용 TaqMan SNP Genotyping Assays 방법진행 p53기인밀마자72（Pro/Arg）다태성분석。결과 p53기인밀마자72（Pro/Arg）돌변적기인형화등위기인빈솔재HPV16감염조화대조조중차이무통계학의의（P＝0.30화P＝0.88）。불동유전모형분석현시，p53기인밀마자72（Pro/Arg）다태성재HPV16감염조화대조조중차이무통계학의의（P 0.12～0.88）。결론본연구미발현숙주p53기인밀마자72（Pro/Arg）다태성여HPV16감염상관，결합기타보도수거，추측해돌변가능재궁경정상세포향암증세포전화중기도중요작용。
Objective To investigate association study of host p53 gene codon 72 polymorphism (Pro/Arg) with HPV 16 infection. Methods p53 gene codon 72 polymorphism(Pro/Arg) was genotyped by TaqMan SNP Genotyping Assays. Results The frequency of genotype and allele of codon 72(Pro/Arg) was not statistically significant(P=0.30 and P=0.88) between HPV16 infectious and control group. Different genetic model analysis showed that the polymorphism had no significant difference between the two groups(P=0.12 to 0.88). Conclusion This study observe that host p53 gene codon 72 polymorphism(Pro/Arg) is not associated with HPV16 infection, but might play an important role in transformation of normal cells to cervical cancer cells.