中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
1期
100-103
,共4页
成纤维细胞生长因子%鼻息肉%伤口愈合
成纖維細胞生長因子%鼻息肉%傷口愈閤
성섬유세포생장인자%비식육%상구유합
Fibroblast growth factor%Nasal polyp%Wound healing
目的:观察重组人酸性成纤维细胞生长因子(rh-aFGF,商品名艾夫吉夫)对鼻息肉术后的创面促愈合作用。方法入选3个研究中心的144例鼻息肉手术患者,术后两组均给予常规抗生素、止血药物、激素或引流治疗。治疗组在此基础上给予rh-aFGF(术中采用2支rh-aFGF溶于20 ml生理盐水冲洗,至第4周最后一次冲洗后,吸收性明胶海绵及凡士林纱布填塞鼻腔,24~48 h后取出后给予1%麻黄碱收敛鼻腔黏膜),对照组则仅给予生理盐水冲洗。近期随访30 d观察创面的愈合状况,远期随访3个月观察患者鼻腔术后的后遗症发生率。结果近期随访研究显示,rh-aFGF可明显促进肉芽组织的生长及上皮化,提高术后的愈合率(62.5%vs.30.5%),减少延迟愈合发生率(16.7% vs.50%)(P<0.05)。远期随访研究显示,重组人酸性成纤维细胞生长因子可缩短完全愈合时间(17.6±6.4 vs.25.4±7.2),两组比较具有统计学差异(P<0.05),同时术后8周随访结果显示rh-aFGF可显著减少息肉复发(3.2%vs.13.6%),窦口狭窄(4.9%vs.16.7%)及术后创面瘙痒(10.6%vs.31.8%)、疼痛(6.5%vs.19.6%)的发生,促进嗅觉的恢复(85.2%vs.71.2%),两组比较均有统计学差异(P<0.05)。结论 rh-aFGF近期可促进术后创面愈合,减少延迟愈合发生,远期可创面瘢痕、术后瘙痒及术后鼻腔痛。
目的:觀察重組人痠性成纖維細胞生長因子(rh-aFGF,商品名艾伕吉伕)對鼻息肉術後的創麵促愈閤作用。方法入選3箇研究中心的144例鼻息肉手術患者,術後兩組均給予常規抗生素、止血藥物、激素或引流治療。治療組在此基礎上給予rh-aFGF(術中採用2支rh-aFGF溶于20 ml生理鹽水遲洗,至第4週最後一次遲洗後,吸收性明膠海綿及凡士林紗佈填塞鼻腔,24~48 h後取齣後給予1%痳黃堿收斂鼻腔黏膜),對照組則僅給予生理鹽水遲洗。近期隨訪30 d觀察創麵的愈閤狀況,遠期隨訪3箇月觀察患者鼻腔術後的後遺癥髮生率。結果近期隨訪研究顯示,rh-aFGF可明顯促進肉芽組織的生長及上皮化,提高術後的愈閤率(62.5%vs.30.5%),減少延遲愈閤髮生率(16.7% vs.50%)(P<0.05)。遠期隨訪研究顯示,重組人痠性成纖維細胞生長因子可縮短完全愈閤時間(17.6±6.4 vs.25.4±7.2),兩組比較具有統計學差異(P<0.05),同時術後8週隨訪結果顯示rh-aFGF可顯著減少息肉複髮(3.2%vs.13.6%),竇口狹窄(4.9%vs.16.7%)及術後創麵瘙癢(10.6%vs.31.8%)、疼痛(6.5%vs.19.6%)的髮生,促進嗅覺的恢複(85.2%vs.71.2%),兩組比較均有統計學差異(P<0.05)。結論 rh-aFGF近期可促進術後創麵愈閤,減少延遲愈閤髮生,遠期可創麵瘢痕、術後瘙癢及術後鼻腔痛。
목적:관찰중조인산성성섬유세포생장인자(rh-aFGF,상품명애부길부)대비식육술후적창면촉유합작용。방법입선3개연구중심적144례비식육수술환자,술후량조균급여상규항생소、지혈약물、격소혹인류치료。치료조재차기출상급여rh-aFGF(술중채용2지rh-aFGF용우20 ml생리염수충세,지제4주최후일차충세후,흡수성명효해면급범사림사포전새비강,24~48 h후취출후급여1%마황감수렴비강점막),대조조칙부급여생리염수충세。근기수방30 d관찰창면적유합상황,원기수방3개월관찰환자비강술후적후유증발생솔。결과근기수방연구현시,rh-aFGF가명현촉진육아조직적생장급상피화,제고술후적유합솔(62.5%vs.30.5%),감소연지유합발생솔(16.7% vs.50%)(P<0.05)。원기수방연구현시,중조인산성성섬유세포생장인자가축단완전유합시간(17.6±6.4 vs.25.4±7.2),량조비교구유통계학차이(P<0.05),동시술후8주수방결과현시rh-aFGF가현저감소식육복발(3.2%vs.13.6%),두구협착(4.9%vs.16.7%)급술후창면소양(10.6%vs.31.8%)、동통(6.5%vs.19.6%)적발생,촉진후각적회복(85.2%vs.71.2%),량조비교균유통계학차이(P<0.05)。결론 rh-aFGF근기가촉진술후창면유합,감소연지유합발생,원기가창면반흔、술후소양급술후비강통。
Objective To study the effect of recombinant human acidic fibroblast growth factor (rh-aFGF) on promoting wound healing after nasal polyp surgery. Methods 144 cases of patients were randomly divided into two groups, the treatment group(n=72, treated with rh-aFGF) and the control group(n=72, treated with placebo). Observation of wound healing, wound area, healing rate, the wound recovering time, the time of granulation growth was recorded after 8 weeks of treatment. Results After 2 weeks of treatment by rh-aFGF, the growth of granulation tissue and epithelialization were promoted, and rh-aFGF application can improve the healing rate(62.5%vs. 30.5%), decrease the delayed union(16.7%vs. 50%). Long-time follow-up showed rh-aFGF can restrain the granulation tissue(3.2%vs. 13.6%), recurrent sinusitis (10.6% vs. 31.8%)and nasal polyps and vesicle (85.2% vs. 71.2%). Conclusions rh-aFGF can promote wound healing after nasal polyp surgery,also it can decrease the sequelae after surgery.