中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
1期
46-49
,共4页
余发斌%黄建宏%熊斌%胡永超%陈晓娟%张绍凤
餘髮斌%黃建宏%熊斌%鬍永超%陳曉娟%張紹鳳
여발빈%황건굉%웅빈%호영초%진효연%장소봉
胃肿瘤%复发%中性粒细胞与淋巴细胞比值%转移淋巴结与切除淋巴结比率
胃腫瘤%複髮%中性粒細胞與淋巴細胞比值%轉移淋巴結與切除淋巴結比率
위종류%복발%중성립세포여림파세포비치%전이림파결여절제림파결비솔
Stomach neoplasms%Recurrence%Neutrophil to lymphocyte ratio%Metastasis lymph nodes ratio
目的：我们对比分析可切除胃癌患者的临床病理资料，试图找出胃癌患者术后复发的早期预知因子。方法该研究包括201例在我院行胃癌根治术的患者，94例患者出现术后复发，107例患者随访无复发。分析对比两组病例的术后病理组织学特征、肿瘤浸润深度、淋巴结转移、术前血清CEA、转移淋巴结与切除淋巴结比率（NR）及术前中性粒细胞与淋巴细胞比值（NLR）等指标，探讨其与胃癌术后复发的关系。结果胃癌术后复发与肿瘤浸润深度、淋巴结转移、NR、NLR、术前血清CEA水平、肿瘤的组织学特征有关（P＜0.05），与肿瘤的部位无关（P＞0.05）；多因素Logistic回归分析表明NLR为胃癌术后复发的独立危险因素。结论 NLR为胃癌术后复发的独立预知因素，能够早期预知胃癌术后复发。
目的：我們對比分析可切除胃癌患者的臨床病理資料，試圖找齣胃癌患者術後複髮的早期預知因子。方法該研究包括201例在我院行胃癌根治術的患者，94例患者齣現術後複髮，107例患者隨訪無複髮。分析對比兩組病例的術後病理組織學特徵、腫瘤浸潤深度、淋巴結轉移、術前血清CEA、轉移淋巴結與切除淋巴結比率（NR）及術前中性粒細胞與淋巴細胞比值（NLR）等指標，探討其與胃癌術後複髮的關繫。結果胃癌術後複髮與腫瘤浸潤深度、淋巴結轉移、NR、NLR、術前血清CEA水平、腫瘤的組織學特徵有關（P＜0.05），與腫瘤的部位無關（P＞0.05）；多因素Logistic迴歸分析錶明NLR為胃癌術後複髮的獨立危險因素。結論 NLR為胃癌術後複髮的獨立預知因素，能夠早期預知胃癌術後複髮。
목적：아문대비분석가절제위암환자적림상병리자료，시도조출위암환자술후복발적조기예지인자。방법해연구포괄201례재아원행위암근치술적환자，94례환자출현술후복발，107례환자수방무복발。분석대비량조병례적술후병리조직학특정、종류침윤심도、림파결전이、술전혈청CEA、전이림파결여절제림파결비솔（NR）급술전중성립세포여림파세포비치（NLR）등지표，탐토기여위암술후복발적관계。결과위암술후복발여종류침윤심도、림파결전이、NR、NLR、술전혈청CEA수평、종류적조직학특정유관（P＜0.05），여종류적부위무관（P＞0.05）；다인소Logistic회귀분석표명NLR위위암술후복발적독립위험인소。결론 NLR위위암술후복발적독립예지인소，능구조기예지위암술후복발。
Objective We attempt to find out the early prognostic factors of recurrence in patients with gastric cancer who received curative resection by means of contrastive analysis of clinicopathological factors. Methods A total of 201 patients with gastric cancer, who underwent curative resection in our hospital were included. A total of 94 patients were found with recurrence, and 107 patients were without recurrence.Various clinicopathological factors including tumor infiltration depth, pathological and histological characteristics, lymph node metastasis, metastasis lymph nodes ratio(NR), neutrophil to lymphocyte ratio(NLR), preoperative serum CEA etc were analyzed retrospectively. Results Chis-Square Test showed that the tumor infiltration depth, lymph node metastasis, NR, NLR, preoperative serum-CEA level and pathological and histological characteristics were statistically significant as risk factors for recurrence(P<0.05), meanwhile the region of tumor were unrelated with the tumor histological characteristics(P>0.05). Multivariate logistic regression analysis revealed that the lymph node metastasis, NR and NLR were independent risk factor among all the clinicopathologic variables. Conclusion The NLR are independent prognostic indicators of recurrence for patients with resectable gastric cancer, it's favourable to early forecast the recurrence in patients with gastric cancer who received curative resection.
