CAJ | 학술논문

目的：对8-甲氧基补骨脂素（8-MOP）柔性纳米脂质体凝胶、8-MOP 柔性纳米脂质体、8-MOP酊剂三种剂型药物的透皮差异进行比较，探讨三种不同剂型8-甲氧基补骨脂素柔性纳米脂质体的大鼠体外透皮性。方法：将三种不同剂型8-MOP通过含有离体鼠皮的扩散池，测定鼠皮以及接受池中8-MOP的含量，并进行比较，对不同时间点3种不同剂型8-MOP的累积渗透量作图，对各组皮肤滞留量两两进行t检验。结果：8-MOP脂质体凝胶组在接受液中的累积渗透量小于8-MOP脂质体组和酊剂组；8-MOP酊剂组渗透量从第3 h后开始急剧升高；比较各组皮肤内滞留的药量，8-MOP脂质体凝胶组高于8-MOP酊剂组，而8-MOP脂质体组又高于MOP脂质体凝胶组，差异均有统计学意义（ t值分别为53.97、18.97， P值均＜0.05）。结论：8-MOP不同剂型有着不同的特性，8-MOP柔性纳米脂质体更具有皮肤亲和性，更有利于药物在皮肤内滞留发挥药物作用。
목적：대8-갑양기보골지소（8-MOP）유성납미지질체응효、8-MOP 유성납미지질체、8-MOP정제삼충제형약물적투피차이진행비교，탐토삼충불동제형8-갑양기보골지소유성납미지질체적대서체외투피성。방법：장삼충불동제형8-MOP통과함유리체서피적확산지，측정서피이급접수지중8-MOP적함량，병진행비교，대불동시간점3충불동제형8-MOP적루적삼투량작도，대각조피부체류량량량진행t검험。결과：8-MOP지질체응효조재접수액중적루적삼투량소우8-MOP지질체조화정제조；8-MOP정제조삼투량종제3 h후개시급극승고；비교각조피부내체류적약량，8-MOP지질체응효조고우8-MOP정제조，이8-MOP지질체조우고우MOP지질체응효조，차이균유통계학의의（ t치분별위53.97、18.97， P치균＜0.05）。결론：8-MOP불동제형유착불동적특성，8-MOP유성납미지질체경구유피부친화성，경유리우약물재피부내체류발휘약물작용。
Objective:To explore the different transdermal effects of three dosage-forms of 8-methoxypsoralen ( 8-MOP ) flexible nano-liposomes including 8-MOP flexible nano liposome , 8-MOP nano-liposome gel and 8-MOP tincture .Methods:Three dosage forms of 8-MOP flexible nano-liposomes were put through the diffusing pool containing rat skin in vitro .The levels of 8-MOP in the rat skin as well as in the receiving pool were measured .The cumulative permeation quantity of three kinds of 8-MOP in different time points were recorded , and the content of 8-MOP in the rat skin of each two groups were compared by t-test.Results:Cumulative infiltration capacity in receiving pool of 8-MOP flexible nano-liposome gel group was obviously lower than that of 8-MOP flexible nano liposome group and 8-MOP tincture group , but the content of the 8-MOP in rat skin of 8-MOP nano-liposome gel groups was superior to that in the 8-MOP tincture group ( t=53.97, P<0.05), which in 8-MOP liposome group was significantly higher than that in 8-MOP liposome gel group (t=18.97, P<0.05).Conclusion:Three dosage forms of 8-MOP have dif-ferent characters , but the flexible nano-liposome form shows better skin affinity and is more condu-cive to drug retention in the skin .