中国癌症杂志
中國癌癥雜誌
중국암증잡지
CHINA ONCOLOGY
2013年
12期
1001-1006
,共6页
Notch3%卵巢癌%信号传导通路
Notch3%卵巢癌%信號傳導通路
Notch3%란소암%신호전도통로
Notch3%Epithelial ovarian cancer%Signaling pathway
Notch信号传导通路是影响细胞命运的重要通路之一，相邻细胞间通过Notch受体传递信号可以调节多种细胞的分化、增殖和凋亡，影响器官形成和形态变化。Notch信号传导的变化与肿瘤的发生发展密切相关，如脑肿瘤、乳腺癌、肝癌等。近年来研究表明，Notch异常通路介导卵巢癌的发生发展，尤其Notch3及其信号传导分子参与肿瘤的化疗耐药与复发。文章对新近有关Notch3信号通路的重要分子调控卵巢癌的发生发展进行综述。
Notch信號傳導通路是影響細胞命運的重要通路之一，相鄰細胞間通過Notch受體傳遞信號可以調節多種細胞的分化、增殖和凋亡，影響器官形成和形態變化。Notch信號傳導的變化與腫瘤的髮生髮展密切相關，如腦腫瘤、乳腺癌、肝癌等。近年來研究錶明，Notch異常通路介導卵巢癌的髮生髮展，尤其Notch3及其信號傳導分子參與腫瘤的化療耐藥與複髮。文章對新近有關Notch3信號通路的重要分子調控卵巢癌的髮生髮展進行綜述。
Notch신호전도통로시영향세포명운적중요통로지일，상린세포간통과Notch수체전체신호가이조절다충세포적분화、증식화조망，영향기관형성화형태변화。Notch신호전도적변화여종류적발생발전밀절상관，여뇌종류、유선암、간암등。근년래연구표명，Notch이상통로개도란소암적발생발전，우기Notch3급기신호전도분자삼여종류적화료내약여복발。문장대신근유관Notch3신호통로적중요분자조공란소암적발생발전진행종술。
Notch signal pathway is one of crucial pathways related to cell fate determination, regulating cell differentiation, proliferation and apoptosis, with an effect of organ formation and morphogenesis. Abnormal activation of Notch gene occurs in many tumor cells, such as brain tumors, breast cancer and hepatoma. Recent studies have been found that the notch pathway out of control was related with growth of ovarian cancer. And Notch3 involving in the development and progression of ovarian cancer has been attracted extensive attention by experts and scholars. This review focuses on the literatures of Notch3 and related molecules regulating the development and progression of epithelial ovarian cancer.
