CAJ | 학술논문

目的：探讨妊娠期高血压疾病(HDCP)患者血清胱抑素C(Cys-C)和尿微量白蛋白(UmAlb)联合检测的临床价值。方法选择HDCP患者143例，其中，妊娠期高血压68例，轻度子痫前期43例，重度子痫前期32例。另选择同期在本院产前体检的30例正常孕妇作为对照组。分别采血及尿液检测血Cys-C、尿素氮(BUN)、肌酐(Scr)和UmAlb水平并进行比较分析。结果妊娠期高血压组、轻度子痫前期组、重度子痫前期组三组患者血清Cys-C及UmAlb水平均显著高于对照组(P均<0.01)；妊娠期高血压组、轻度子痫前期组、重度子痫前期组三组间Cys-C和UmAlb水平比较，差异均有统计学意义(妊娠期高血压组<轻度子痫前期组<重度子痫前期组， P均<0.01)。重度子痫前期组血BUN和Scr水平均明显高于对照组(P<0.01)，而妊娠期高血压组、轻度子痫前期组血BUN、Scr水平与对照组比较，差异均无统计学意义(P均>0.05)。结论血清Cys-C和UmAlb均为反映HDCP患者早期肾功能损害的敏感指标，两者联合检测对HDCP早期肾损害的诊断有重要价值。
목적：탐토임신기고혈압질병(HDCP)환자혈청광억소C(Cys-C)화뇨미량백단백(UmAlb)연합검측적림상개치。방법선택HDCP환자143례，기중，임신기고혈압68례，경도자간전기43례，중도자간전기32례。령선택동기재본원산전체검적30례정상잉부작위대조조。분별채혈급뇨액검측혈Cys-C、뇨소담(BUN)、기항(Scr)화UmAlb수평병진행비교분석。결과임신기고혈압조、경도자간전기조、중도자간전기조삼조환자혈청Cys-C급UmAlb수평균현저고우대조조(P균<0.01)；임신기고혈압조、경도자간전기조、중도자간전기조삼조간Cys-C화UmAlb수평비교，차이균유통계학의의(임신기고혈압조<경도자간전기조<중도자간전기조， P균<0.01)。중도자간전기조혈BUN화Scr수평균명현고우대조조(P<0.01)，이임신기고혈압조、경도자간전기조혈BUN、Scr수평여대조조비교，차이균무통계학의의(P균>0.05)。결론혈청Cys-C화UmAlb균위반영HDCP환자조기신공능손해적민감지표，량자연합검측대HDCP조기신손해적진단유중요개치。
Objective To explore the clinical value of detecting serum cystatin-C (Cys-C) combined with urine microalbumin(UmAlb) for patients with hypertensive disorder complicating pregnancy(HDCP). Methods 143 patients with HDCP were selected, including pregnancy-induced hypertension of 68 cases, mild pre-eclampsia of 43 cases and severe-eclampsia of 32 cases. Moreover, 30 normal pregnant women were served as control group. The levels of serum Cys-C, blood urea nitrogen(BUN), serum creatinine(Scr) and UmAlb were detected and compared. Results The levels of serum Cys-C and UmAlb in pregnancy-induced hypertension group, mild pre-eclampsia group and severe-eclampsia group were significantly higher than the control (P<0.01). There were significantly differences among pregnancy-induced hypertension group, mild pre-eclampsia group and severe-eclampsia group of levels of Cys-C and UmAlb(pregnancy-induced hypertension group<mild pre-eclampsia group<severe-eclampsia group, P<0.01). The levels of BUN and Scr of severe-eclampsia group were significantly higher than the control (P<0.01), but they had no significant difference among pregnancy-induced hypertension group, mild pre-eclampsia group and control group (P>0.05). Conclusion Serum Cys-C and UmAlb are sensitive indicators to reflect early renal damage of HDCP patients. Detection of serum Cys-C combined with UmAlb in HDCP patients is helpful to early diagnosis of renal damage.