中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2014年
7期
430-432
,共3页
沐舒坦%糜蛋白酶%雾化吸入%新生儿肺炎
沐舒坦%糜蛋白酶%霧化吸入%新生兒肺炎
목서탄%미단백매%무화흡입%신생인폐염
Mucosolvan%Chymotrypsin%Atomizing inhalation%Neonatal pneumonia
目的 探讨沐舒坦和糜蛋白酶不同雾化方式治疗新生儿肺炎的临床疗效及安全性.方法 将我院2011年7月至2013年8月明确诊断的78例新生儿肺炎患儿按照随机数字表法随机分为治疗组和对照组,每组39例.两组患儿在综合治疗基础上,对照组应用糜蛋白酶雾化,治疗组予沐舒坦压缩雾化,观察两组治疗疗效.结果 与治疗后24、48、72 h比较,治疗组患儿PaO2较对照组明显上升,PaCO2较对照组明显下降,氧合指数较对照组升高明显改善,差异均有统计学意义(P＜0.01).治疗组在症状缓解、体征消失时间和住院天数较对照组缩短,与对照组比较差异有统计学意义(P＜0.01);治疗组中显效25例,有效9例,无效5例,有效率为87.2％.对照组中显效14例,有效6例,无效19例,有效率为51.3％,两组间差异有统计学意义(P＜0.01).两组在治疗过程中均未发现相关的药物不良反应.结论 雾化吸入治疗新生儿肺炎沐舒坦疗效优于糜蛋白酶,缩短疗程,值得推广应用.
目的 探討沐舒坦和糜蛋白酶不同霧化方式治療新生兒肺炎的臨床療效及安全性.方法 將我院2011年7月至2013年8月明確診斷的78例新生兒肺炎患兒按照隨機數字錶法隨機分為治療組和對照組,每組39例.兩組患兒在綜閤治療基礎上,對照組應用糜蛋白酶霧化,治療組予沐舒坦壓縮霧化,觀察兩組治療療效.結果 與治療後24、48、72 h比較,治療組患兒PaO2較對照組明顯上升,PaCO2較對照組明顯下降,氧閤指數較對照組升高明顯改善,差異均有統計學意義(P＜0.01).治療組在癥狀緩解、體徵消失時間和住院天數較對照組縮短,與對照組比較差異有統計學意義(P＜0.01);治療組中顯效25例,有效9例,無效5例,有效率為87.2％.對照組中顯效14例,有效6例,無效19例,有效率為51.3％,兩組間差異有統計學意義(P＜0.01).兩組在治療過程中均未髮現相關的藥物不良反應.結論 霧化吸入治療新生兒肺炎沐舒坦療效優于糜蛋白酶,縮短療程,值得推廣應用.
목적 탐토목서탄화미단백매불동무화방식치료신생인폐염적림상료효급안전성.방법 장아원2011년7월지2013년8월명학진단적78례신생인폐염환인안조수궤수자표법수궤분위치료조화대조조,매조39례.량조환인재종합치료기출상,대조조응용미단백매무화,치료조여목서탄압축무화,관찰량조치료료효.결과 여치료후24、48、72 h비교,치료조환인PaO2교대조조명현상승,PaCO2교대조조명현하강,양합지수교대조조승고명현개선,차이균유통계학의의(P＜0.01).치료조재증상완해、체정소실시간화주원천수교대조조축단,여대조조비교차이유통계학의의(P＜0.01);치료조중현효25례,유효9례,무효5례,유효솔위87.2％.대조조중현효14례,유효6례,무효19례,유효솔위51.3％,량조간차이유통계학의의(P＜0.01).량조재치료과정중균미발현상관적약물불량반응.결론 무화흡입치료신생인폐염목서탄료효우우미단백매,축단료정,치득추엄응용.
Objective To investigate the clinical efficacy and its security on different kinds of atomization with mucosolvan and chymotrypsin in treating neonatal pneumonia.Methods Seventy-eight neonates who were diagnosed as neonatal pneumonia were divided into treatment group (n =39) and control group (n =39) by random number table method from Jul 2011 to Aug 2013 in our hospital.The control group was treated with chymotrypsin atomization,and the treatment group was treated with compression atomizing to inhale mucosolvan.The treatment effects of two groups were compared.Results Compared with the control group after treatment for 24 h,48 h,72 h,the treatment group had more significant increasing in PaO2,more decreasing in PaCO2 and more significant improvement in oxygenation index.There were statistical significances between the two groups(P ＜ 0.01).The treatment group spent shorter time in remission of symptoms,disappear of signs and hospital stay than that of the control group(P ＜ 0.05).In the treatment group,25 cases were markedly improved,9 cases were effective,5 cases were invalid.The effective rate was 87.2％.In the control group,14 cases were markedly effective,6 cases were effective,19 cases were invalid.The effective rate was 51.3％.The effective rate was significant difference between the two groups (P ＜ 0.01).The adverse drug reactions were not found in the process of treatment for two groups.Conclusion Mucosolvan atomizing inhalation has a better treatment effect than chymotrypsin.It can shorten the course of treatment,and is worth promoting the application.
