中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
z1期
66-68
,共3页
瘦素%脂联素%冠状动脉疾病
瘦素%脂聯素%冠狀動脈疾病
수소%지련소%관상동맥질병
Leptin%Adiponectin%Coronary artery disease
目的 探讨中老年冠心病患者血清瘦素和脂联素的表达及相关性.方法 选取88例年龄≥55岁行冠状动脉造影的患者,根据造影结果分为冠心病组52例和对照组36例,采用酶联免疫吸附试验法测定血清瘦素和脂联素水平.结果 冠心病组患者血清瘦素水平高于对照组[(9.38±3.51) μg/L比(7.27±3.25) μg/L,P＜0.05],脂联素水平低于对照组[(11.08±3.87) mg/L比(13.34±4.94) mg/L,P＜0.05],Logistic多元回归分析显示仅有血清瘦素水平是中老年冠心病的独立危险因素.Spearman相关分析显示,血清脂联素与瘦素水平呈负相关(r=-0.320,P=0.002).结论 中老年冠心病患者血清脂联素水平的降低与瘦素水平的升高相关,血清瘦素水平的升高是冠心病的独立危险因素,而血清脂联素水平降低并不是冠心病的独立危险因素.
目的 探討中老年冠心病患者血清瘦素和脂聯素的錶達及相關性.方法 選取88例年齡≥55歲行冠狀動脈造影的患者,根據造影結果分為冠心病組52例和對照組36例,採用酶聯免疫吸附試驗法測定血清瘦素和脂聯素水平.結果 冠心病組患者血清瘦素水平高于對照組[(9.38±3.51) μg/L比(7.27±3.25) μg/L,P＜0.05],脂聯素水平低于對照組[(11.08±3.87) mg/L比(13.34±4.94) mg/L,P＜0.05],Logistic多元迴歸分析顯示僅有血清瘦素水平是中老年冠心病的獨立危險因素.Spearman相關分析顯示,血清脂聯素與瘦素水平呈負相關(r=-0.320,P=0.002).結論 中老年冠心病患者血清脂聯素水平的降低與瘦素水平的升高相關,血清瘦素水平的升高是冠心病的獨立危險因素,而血清脂聯素水平降低併不是冠心病的獨立危險因素.
목적 탐토중노년관심병환자혈청수소화지련소적표체급상관성.방법 선취88례년령≥55세행관상동맥조영적환자,근거조영결과분위관심병조52례화대조조36례,채용매련면역흡부시험법측정혈청수소화지련소수평.결과 관심병조환자혈청수소수평고우대조조[(9.38±3.51) μg/L비(7.27±3.25) μg/L,P＜0.05],지련소수평저우대조조[(11.08±3.87) mg/L비(13.34±4.94) mg/L,P＜0.05],Logistic다원회귀분석현시부유혈청수소수평시중노년관심병적독립위험인소.Spearman상관분석현시,혈청지련소여수소수평정부상관(r=-0.320,P=0.002).결론 중노년관심병환자혈청지련소수평적강저여수소수평적승고상관,혈청수소수평적승고시관심병적독립위험인소,이혈청지련소수평강저병불시관심병적독립위험인소.
Objective To investigate serum leptin and adiponectin levels and their relationship in elderly coronary artery disease (CAD).Methods A total of 88 subjects aged 55 yeas or older were enrolled in which coronary angiograms were performed.The subjects were divided into CAD group (52 patients) and control group (36 patients) by angiography.Serum concentrations of leptin and adiponectin were evaluated by ELISA system.Results Serum concentrations of leptin were significantly increased in CAD group compared with that in control group [(9.38 ±3.51) μg/L vs.(7.27 ±3.25) μg/L,P ＜0.05].On the contrary,serum concentrations of adiponectin were significantly decreased in CAD group compared with that in control group [(11.08 ±3.87) mg/L vs.(13.34 ±4.94) mg/L,P＜0.05].Logistic regression analysis revealed that only serum leptin was the independent risk factor for CAD.Serum adiponectin concentrations had a negative relationship with leptin concentrations (r =-0.320,P =0.002).Conclusion Lower serum adiponectin levels are related to higher serum leptin concentrations.Elevated serum leptin but not decreased serum adiponectin is the independent risk factor for CAD.
