CAJ | 학술논문

采用正交试验法筛选阿昔洛韦固体脂质纳米粒最优处方。利用（W/O/W）复乳-超声法制备阿昔洛韦固体脂质纳米粒,以包封率为评价指标,采用L9（34）正交试验设计筛选出最优处方。单硬脂酸甘油酯用量1.5%、大豆卵磷脂用量0.4%、泊洛沙姆188浓度2%、油相与内水相体积比（Vo/V）i 6。正交试验优化阿昔洛韦固体纳米粒处方有效、可行。
채용정교시험법사선아석락위고체지질납미립최우처방。이용（W/O/W）복유-초성법제비아석락위고체지질납미립,이포봉솔위평개지표,채용L9（34）정교시험설계사선출최우처방。단경지산감유지용량1.5%、대두란린지용량0.4%、박락사모188농도2%、유상여내수상체적비（Vo/V）i 6。정교시험우화아석락위고체납미립처방유효、가행。
In this study, we screen the optimum prescription of Acyclovir solid lipid Nanoparticles with orthogonal test method. The Acyclovir solid lipid Nanoparticles is prepared by multiple-emulsion-ultrasound method, the entrapment efficiency is used as the evaluation index, and the optimum prescription is designed by L9 （34） orthogonal test. The amount of monostearate is 1.5%, the amount of soybean lecithin is 0.4%, the concentration of Poloxamer188 is 2%, and the phase volume ratio （Vo/Vi） is 6. The result show that the optimization of Acyclovir solid Nanoparticles with orthogonal test is effective and feasible.