中国男科学杂志
中國男科學雜誌
중국남과학잡지
CHINESE JOURNAL OF ANDROLOGY
2014年
2期
36-39
,共4页
朱宏%陈斌%王鸿祥%胡凯%金炎%杨昊%冯坦%张涛%韩银发%王益鑫%黄翼然
硃宏%陳斌%王鴻祥%鬍凱%金炎%楊昊%馮坦%張濤%韓銀髮%王益鑫%黃翼然
주굉%진빈%왕홍상%호개%금염%양호%풍탄%장도%한은발%왕익흠%황익연
人体质量指数%生育力%不育,男性
人體質量指數%生育力%不育,男性
인체질량지수%생육력%불육,남성
body mass index%fertility%infertility,male
目的：探究不育男性体重指数（body mass index, BMI）与精液参数、血清性激素及抑制素B（Inhibin B）水平的关系。方法随机选择2012年1月至2012年12月就诊上海交通大学医学院附属仁济医院男科门诊的男性不育症患者317例，按照BMI≥28为肥胖，BMI 24~27.9为超重，BMI 18.5~23.9为正常进行分组。检测常规精液参数、血清性激素水平，并进行统计学分析。结果超重组精子浓度、精子总数、活动精子总数、c级精子百分数、血清T、Inhibin B水平及T/E2均低于正常体重组，d级精子百分数血清E2水平高于正常体重组。肥胖组精子浓度、精子总数、活力、活动精子总数、a级、b级、c级精子百分数、血清T、Inhibin B水平及T/E2均低于正常体重组，d级精子百分数、血清E2水平高于正常体重组。BMI与年龄、血清E2水平呈正相关，BMI与精子浓度、精子总数、c级精子百分数、血清T、T/E2及Inhibin B水平均呈负相关。差异均有统计学意义。结论随着男性BMI的增加，精液参数可发生不同程度下降，同时伴有血清性激素的改变，BMI的增加可能是影响男性生育能力的因素之一，其中具体的分子机制仍有待进一步探究。
目的：探究不育男性體重指數（body mass index, BMI）與精液參數、血清性激素及抑製素B（Inhibin B）水平的關繫。方法隨機選擇2012年1月至2012年12月就診上海交通大學醫學院附屬仁濟醫院男科門診的男性不育癥患者317例，按照BMI≥28為肥胖，BMI 24~27.9為超重，BMI 18.5~23.9為正常進行分組。檢測常規精液參數、血清性激素水平，併進行統計學分析。結果超重組精子濃度、精子總數、活動精子總數、c級精子百分數、血清T、Inhibin B水平及T/E2均低于正常體重組，d級精子百分數血清E2水平高于正常體重組。肥胖組精子濃度、精子總數、活力、活動精子總數、a級、b級、c級精子百分數、血清T、Inhibin B水平及T/E2均低于正常體重組，d級精子百分數、血清E2水平高于正常體重組。BMI與年齡、血清E2水平呈正相關，BMI與精子濃度、精子總數、c級精子百分數、血清T、T/E2及Inhibin B水平均呈負相關。差異均有統計學意義。結論隨著男性BMI的增加，精液參數可髮生不同程度下降，同時伴有血清性激素的改變，BMI的增加可能是影響男性生育能力的因素之一，其中具體的分子機製仍有待進一步探究。
목적：탐구불육남성체중지수（body mass index, BMI）여정액삼수、혈청성격소급억제소B（Inhibin B）수평적관계。방법수궤선택2012년1월지2012년12월취진상해교통대학의학원부속인제의원남과문진적남성불육증환자317례，안조BMI≥28위비반，BMI 24~27.9위초중，BMI 18.5~23.9위정상진행분조。검측상규정액삼수、혈청성격소수평，병진행통계학분석。결과초중조정자농도、정자총수、활동정자총수、c급정자백분수、혈청T、Inhibin B수평급T/E2균저우정상체중조，d급정자백분수혈청E2수평고우정상체중조。비반조정자농도、정자총수、활력、활동정자총수、a급、b급、c급정자백분수、혈청T、Inhibin B수평급T/E2균저우정상체중조，d급정자백분수、혈청E2수평고우정상체중조。BMI여년령、혈청E2수평정정상관，BMI여정자농도、정자총수、c급정자백분수、혈청T、T/E2급Inhibin B수평균정부상관。차이균유통계학의의。결론수착남성BMI적증가，정액삼수가발생불동정도하강，동시반유혈청성격소적개변，BMI적증가가능시영향남성생육능력적인소지일，기중구체적분자궤제잉유대진일보탐구。
Objective To study the association between body mass index and semen parameters, gonadotropic and sex hormone, Inhibin B levels in infertile men. Methods 317 infertile men visited outpatient clinic for reproductive treatment and preconception counseling in Renji hospital from January 2012 to December 2012. BMI was assessed and the subjects stratified into subgroups according to BMI, normal-weight:18.5~23.9, overweight:24~27.9 and obese:≥28. The sperm parameters were detected by computer assisted sperm analysis (CASA) and a morning blood sample was taken to assess the levels of serum FSH, LH, testosterone, estradiol and Inhibin B. Results Overweight group had significant decrease in sperm concentration, total sperm count, total motile sperm count, the percentage of immotility type C, serum T level, Inhibin B level and T/E2 ratio compared with normal-weight group, while increase in the percentage of immotility type D and serum E2 level. Obese group had significant decrease in sperm concentration, total sperm count, sperm motility, total motile sperm count, the percentage of progressive motility type A+B, the percentage of immotility type C, serum T level, Inhibin B level, T/E2 ratio compared with normal-weight group, while increase in the percentage of immotility type D and serum E2 level. BMI was significant positively associated with age, serum E2 level and significant negatively associated with sperm concentration, total sperm count, the percentage of immotility type C, serum T level, Inhibin B level, T/E2 ratio. Conclusion The association explored between BMI and some semen characteristics and sexual hormones, as well as different patterns of this association between overweight and obsess infertile men, will be of help to broaden our understanding of the effect of obesity on some male reproductive physiologic characteristics among infertile men.
