CAJ | 학술논문

肝癌是我国常见的恶性肿瘤之一，其恶性程度高，治疗效果差，被誉为“癌中之王”。尽管现在监督程序及检测手段不断发展，但大多数患者患病初期症状不明显，一旦被确诊，也因已处于中晚期而失去了手术机会，因此肝癌的早期诊断对患者的治疗尤为重要。糖蛋白的异常与恶性肿瘤的侵袭、转移、耐药机制等密切相关，所以针对肝癌相关糖蛋白进行研究，一方面有助于发现敏感性更高、特异性更强的肝癌血清学标志物，对肝癌的早期诊断提供帮助，另一方面肝癌细胞经化疗后容易产生多药耐药，这可能与肝癌相关的一些糖蛋白修饰改变相关，所以肝癌相关糖蛋白的研究还对提高肝癌化疗效果具有重要意义。本文就肝癌相关糖蛋白改变做如下综述。
간암시아국상견적악성종류지일，기악성정도고，치료효과차，피예위“암중지왕”。진관현재감독정서급검측수단불단발전，단대다수환자환병초기증상불명현，일단피학진，야인이처우중만기이실거료수술궤회，인차간암적조기진단대환자적치료우위중요。당단백적이상여악성종류적침습、전이、내약궤제등밀절상관，소이침대간암상관당단백진행연구，일방면유조우발현민감성경고、특이성경강적간암혈청학표지물，대간암적조기진단제공방조，령일방면간암세포경화료후용역산생다약내약，저가능여간암상관적일사당단백수식개변상관，소이간암상관당단백적연구환대제고간암화료효과구유중요의의。본문취간암상관당단백개변주여하종술。
Liver cancer is one of the most common cancer in our country, it is known as"the king of cancer" with high malignant degree and poor treatment effect. Despite recent improvements in surveillance programs and diagnostic tools, the symptom is not obvious at the beginning of the disease for most patients, once diagnosed, they often lose the opportunity for liver resection, so early diagnosis is very important for liver cancer therapy. The abnormal glycoproteins is associated with the invasion, metastasis, resistance mechanism of malignant tumour, so study for glycoproteins can contribute to find new serum biomarkers with higher sensibility and specificity which is helpful for early diagnosis of liver cancer. Besides, chemotherapy often leads to multidrug resistance in hepatic cellular carcinoma, modify changes of glycoprotein may be one of the reasons, so it’s also significant for promoting chemotherapeutic effect. This review described about the changes of liver cancer related glycoprotein.