CAJ | 학술논문

目的：通过对卒中后患者在年龄、性别、病程、卒中类型、基础疾病、血压、生化指标、神经心理学特点、经济支持等方面与卒中后抑郁发生的相关性研究，进一步发现相关度较高的一些因素，对今后的卒中后抑郁的防治提供依据。方法选取上海养志康复医院自2012年5月至2013年10月住院治疗的卒中后患者，在排除严重言语障碍及认知功能障碍后，根据DSM-Ⅳ的抑郁症诊断标准及MADRS评分，将入组患者分为病例组与对照组。所有患者均接受生化检查及访谈评估。分析比较病例组与对照组在上述各项指标方面的差异及相关性。结果回顾两组患者，在卒中次数（OR＝2.862）、TIA发作（OR＝2.596）、高血压（OR＝2.528）、急性起病（OR＝4.678）等方面具有明显的相关性，简易认知功能检查及自理能力、社会活动功能及物体命名能力方面差异有统计学意义（P＜0.05）。结论卒中后抑郁的发生更多地取决于血管性疾病，尤其是高血压的治疗与控制，同时既往卒中发生及TIA发作对于卒中后抑郁的发生同样不利，认知能力及社会功能的完整性对于卒中后抑郁的发生具有积极意义。
목적：통과대졸중후환자재년령、성별、병정、졸중류형、기출질병、혈압、생화지표、신경심이학특점、경제지지등방면여졸중후억욱발생적상관성연구，진일보발현상관도교고적일사인소，대금후적졸중후억욱적방치제공의거。방법선취상해양지강복의원자2012년5월지2013년10월주원치료적졸중후환자，재배제엄중언어장애급인지공능장애후，근거DSM-Ⅳ적억욱증진단표준급MADRS평분，장입조환자분위병례조여대조조。소유환자균접수생화검사급방담평고。분석비교병례조여대조조재상술각항지표방면적차이급상관성。결과회고량조환자，재졸중차수（OR＝2.862）、TIA발작（OR＝2.596）、고혈압（OR＝2.528）、급성기병（OR＝4.678）등방면구유명현적상관성，간역인지공능검사급자리능력、사회활동공능급물체명명능력방면차이유통계학의의（P＜0.05）。결론졸중후억욱적발생경다지취결우혈관성질병，우기시고혈압적치료여공제，동시기왕졸중발생급TIA발작대우졸중후억욱적발생동양불리，인지능력급사회공능적완정성대우졸중후억욱적발생구유적겁의의。
Objective To explore the correlation between biology, socio-economic risk factors and the PSD occurrence from comparing the PSD patients and the non-PSD patients. Provide the prevention and treatment of post-stroke depression future. Methods A total of 187 patients with stroke were divided into two groups PSD or non-PSD by DSM-Ⅳ and MADRS. All the patients completed the interview, biochemical tests and neuropsychological tests. Results Reviewed the two groups, we found significant correlation in the number of stroke(OR=2.862), TIA(OR=2.596), hypertension(OR=2.528), acute onset(OR=4.678). There was significant difference in MMSE, FAQ, BNT between two groups(P<0.05). Conclusions The occurrence of depression after stroke depends more vascular disease, particular for the treatment and control of hypertension. Meanwhile, previous episodes of stroke and TIA for post-stroke depression occurs equally unfavorable. Also the integrity of the cognitive and social functions for the occurrence of post-stroke depression has a positive meaning.