国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
13期
1874-1878
,共5页
吴广伟%朱克武%李茂清%陈美玲%肖学义
吳廣偉%硃剋武%李茂清%陳美玲%肖學義
오엄위%주극무%리무청%진미령%초학의
温脾补肾法%中药%HIV/AIDS%免疫
溫脾補腎法%中藥%HIV/AIDS%免疫
온비보신법%중약%HIV/AIDS%면역
Warming spleen and tonifying kidney%Traditional Chinese medicine%Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)%Immunity
目的 探讨温脾补肾法联合高效抗逆转录病毒疗法(HAART)对HIV/AIDS患者免疫功能的影响.方法 将30例HIV/AIDS患者分为中西医结合治疗组(治疗组)14例,西医治疗组(对照组)16例.对照组采用HAART疗法,治疗组在此基础上联合以温脾补肾法为组方原则的中药艾可清优化处方治疗,共治疗6个月.监测全部患者治疗前、后的卡洛夫斯基积分、临床症状、外周血T淋巴细胞亚群CD4+计数及CD4+/CD8+比值、血常规及肝肾功能等,并综合比较两组的临床疗效.结果 ①治疗后治疗组、对照组的临床受益率分别100.0％和87.5％,两组比较差异有统计学意义(P＜0.05);②治疗后治疗组卡洛夫斯基积分、体重有所改善(P＜0.05),在改善中医临床症状乏力、纳呆及总积分方面也优于对照组(P＜0.05);③治疗后治疗组CD4+细胞计数、白细胞计数分别为(264.97±52.94)个/mm3和(6.94±0.97)×109/L,优于对照组的(238.73±50.13)个/mm3和(5.57±1.29)×109/L (P＜0.05);④两组在治疗期间未出现明显不良反应.结论温脾补肾法联合HAART治疗HIV/AIDS患者可明显地改善临床症状,并能增强机体的免疫功能和提高生活质量,对于实现本病的功能性治愈可起到一定的作用.
目的 探討溫脾補腎法聯閤高效抗逆轉錄病毒療法(HAART)對HIV/AIDS患者免疫功能的影響.方法 將30例HIV/AIDS患者分為中西醫結閤治療組(治療組)14例,西醫治療組(對照組)16例.對照組採用HAART療法,治療組在此基礎上聯閤以溫脾補腎法為組方原則的中藥艾可清優化處方治療,共治療6箇月.鑑測全部患者治療前、後的卡洛伕斯基積分、臨床癥狀、外週血T淋巴細胞亞群CD4+計數及CD4+/CD8+比值、血常規及肝腎功能等,併綜閤比較兩組的臨床療效.結果 ①治療後治療組、對照組的臨床受益率分彆100.0％和87.5％,兩組比較差異有統計學意義(P＜0.05);②治療後治療組卡洛伕斯基積分、體重有所改善(P＜0.05),在改善中醫臨床癥狀乏力、納呆及總積分方麵也優于對照組(P＜0.05);③治療後治療組CD4+細胞計數、白細胞計數分彆為(264.97±52.94)箇/mm3和(6.94±0.97)×109/L,優于對照組的(238.73±50.13)箇/mm3和(5.57±1.29)×109/L (P＜0.05);④兩組在治療期間未齣現明顯不良反應.結論溫脾補腎法聯閤HAART治療HIV/AIDS患者可明顯地改善臨床癥狀,併能增彊機體的免疫功能和提高生活質量,對于實現本病的功能性治愈可起到一定的作用.
목적 탐토온비보신법연합고효항역전록병독요법(HAART)대HIV/AIDS환자면역공능적영향.방법 장30례HIV/AIDS환자분위중서의결합치료조(치료조)14례,서의치료조(대조조)16례.대조조채용HAART요법,치료조재차기출상연합이온비보신법위조방원칙적중약애가청우화처방치료,공치료6개월.감측전부환자치료전、후적잡락부사기적분、림상증상、외주혈T림파세포아군CD4+계수급CD4+/CD8+비치、혈상규급간신공능등,병종합비교량조적림상료효.결과 ①치료후치료조、대조조적림상수익솔분별100.0％화87.5％,량조비교차이유통계학의의(P＜0.05);②치료후치료조잡락부사기적분、체중유소개선(P＜0.05),재개선중의림상증상핍력、납태급총적분방면야우우대조조(P＜0.05);③치료후치료조CD4+세포계수、백세포계수분별위(264.97±52.94)개/mm3화(6.94±0.97)×109/L,우우대조조적(238.73±50.13)개/mm3화(5.57±1.29)×109/L (P＜0.05);④량조재치료기간미출현명현불량반응.결론온비보신법연합HAART치료HIV/AIDS환자가명현지개선림상증상,병능증강궤체적면역공능화제고생활질량,대우실현본병적공능성치유가기도일정적작용.
Objective To investigate the effects of warming spleen and tonifying kidney combined with highly active antiretroviral therapy (HAART) on immune function of human immunodeficiency virus (HIV)/ acquired immunodeficiency syndrome (AIDS) patients.Methods 30 patients with HIV/AIDS were divided into integrated traditional Chinese and western medicine treatment group (the treatment group) with 14 cases,western medicine control group (the control group) with 16 cases.The control group was given HAART,while the treatment group was given warming spleen and tonifying kidney combined with HAART.The treatment course for both groups was six months.Karovsky Performance Status,clinical symptoms,CD4+T cell count,CD4+/CD8+,blood routine,liver and kidney function of two groups were observed before and after treatment,and we compared the clinical efficacy of two groups.Results ① Clinical benefit rate of treatment group and control group were 100％ and 87.5％ respectively,the difference between 2 groups was statistically significant (P ＜ 0.05); ② Karovsky performance status and weight were improved in the treatment group (P ＜ 0.05) and the TCM symptoms asthenia,the total clinical syndrome scores were better than those of control group after the treatment (all P ＜ 0.05).③ CD4+ cell and white blood cell count of the treatment group were (264.97 ± 52.94)/mm3 and (6.94 ± 0.97)109/ L,which were better than (238.73 ± 50.13)/mm3 and (5.57 ± 1.29) 109/L in the control group (P ＜ 0.05); ④ There was no obvious adverse reaction during treatment in two groups.Conclusion Warming spleen and tonifying kidney combined with HAART therapy can significantly improve the clinical symptoms of HIV/AIDS patients,and can enhance immune function and improve their quality of life,which may play a certain role in realization functional cure of HIV/AIDS.
