中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
6期
1-3
,共3页
姜雪滨%宋芳华%单丹妮%尹晓芹
薑雪濱%宋芳華%單丹妮%尹曉芹
강설빈%송방화%단단니%윤효근
心包%引流术%恶性心包积液%香菇多糖
心包%引流術%噁性心包積液%香菇多糖
심포%인류술%악성심포적액%향고다당
Pericardium%Drainage%Pericardial effusion%Lentinan
目的 观察导管持续引流心包积液联合香菇多糖心包腔内灌注对肺癌导致恶性心包积液的疗效及不良反应.方法 选择118例经病理学或细胞学检查证实为肺癌并导致恶性心包积液患者,按照随机数字表法分为治疗组56例与对照组62例,治疗组患者行中心静脉导管持续引流后接受香菇多糖心包腔内灌注；对照组患者行中心静脉导管持续引流后接受顺铂心包腔内灌注,比较两组疗效及不良反应.结果 治疗组有效率89.3％(50/56),对照组有效率83.9％(52/62),两组比较差异无统计学意义(x2=0.736,P=0.391).治疗组不良反应发生率[8.9％(5/56)]低于对照组[24.2％(15/62)],差异有统计学意义(x2=4.871,P=0.027).治疗组与对照组复发率比较差异无统计学意义[14.3％(8/56)比11.3％ (7/62)](x2=0.004,P=0.948).结论 导管持续引流心包积液联合香菇多糖心包腔内灌注治疗肺癌导致恶性心包积液安全、有效,可作为肺癌导致恶性心包积液的首选治疗方法.
目的 觀察導管持續引流心包積液聯閤香菇多糖心包腔內灌註對肺癌導緻噁性心包積液的療效及不良反應.方法 選擇118例經病理學或細胞學檢查證實為肺癌併導緻噁性心包積液患者,按照隨機數字錶法分為治療組56例與對照組62例,治療組患者行中心靜脈導管持續引流後接受香菇多糖心包腔內灌註；對照組患者行中心靜脈導管持續引流後接受順鉑心包腔內灌註,比較兩組療效及不良反應.結果 治療組有效率89.3％(50/56),對照組有效率83.9％(52/62),兩組比較差異無統計學意義(x2=0.736,P=0.391).治療組不良反應髮生率[8.9％(5/56)]低于對照組[24.2％(15/62)],差異有統計學意義(x2=4.871,P=0.027).治療組與對照組複髮率比較差異無統計學意義[14.3％(8/56)比11.3％ (7/62)](x2=0.004,P=0.948).結論 導管持續引流心包積液聯閤香菇多糖心包腔內灌註治療肺癌導緻噁性心包積液安全、有效,可作為肺癌導緻噁性心包積液的首選治療方法.
목적 관찰도관지속인류심포적액연합향고다당심포강내관주대폐암도치악성심포적액적료효급불량반응.방법 선택118례경병이학혹세포학검사증실위폐암병도치악성심포적액환자,안조수궤수자표법분위치료조56례여대조조62례,치료조환자행중심정맥도관지속인류후접수향고다당심포강내관주；대조조환자행중심정맥도관지속인류후접수순박심포강내관주,비교량조료효급불량반응.결과 치료조유효솔89.3％(50/56),대조조유효솔83.9％(52/62),량조비교차이무통계학의의(x2=0.736,P=0.391).치료조불량반응발생솔[8.9％(5/56)]저우대조조[24.2％(15/62)],차이유통계학의의(x2=4.871,P=0.027).치료조여대조조복발솔비교차이무통계학의의[14.3％(8/56)비11.3％ (7/62)](x2=0.004,P=0.948).결론 도관지속인류심포적액연합향고다당심포강내관주치료폐암도치악성심포적액안전、유효,가작위폐암도치악성심포적액적수선치료방법.
Objective To evaluate the effect and safety of catheter constant drainage combined with pericardial perfusion lentinan in treatment of patients with malignant pericardial effusion caused by lung cancer.Methods One hundred and eighteen patients with malignant pericardial effusion caused by lung cancer were divided into 2 groups by table of random digit,the treatment group (56 cases) was treated by pericardial perfusion lentinan after catheter constant drainage by central venous catheter,and the control group (62 cases) was treated by pericardial perfusion cisplatin after catheter constant drainage by central venous catheter.The therapeutic effect and adverse reaction were contrasted between the two groups.Results There was no significant difference in effective rate between treatment group and control group [89.3％(50/56) vs.83.9％ (52/62),x2 =0.736,P =0.391].The adverse reaction rate of treatment group was significantly lower than that of control group [8.9％ (5/56) vs.24.2％ (15/62),x2 =4.871,P =0.027].There was no significant difference in recurrence rate between treatment group and control group [14.3％(8/56) vs.11.3％(7/62),x2 =0.004,P =0.948].Conclusions Catheter constant drainage combined with pericardial perfusion lentinan for malignant pericardial effusion caused by lung cancer is safety and effective,and can be widely applied to clinical application.
