中华老年多器官疾病杂志
中華老年多器官疾病雜誌
중화노년다기관질병잡지
CHINESE JOURNAL OF MULTIPLE ORGAN DISEASES IN THE ELDERLY
2014年
4期
259-262
,共4页
全锦花%张新超%张堃%米玉红
全錦花%張新超%張堃%米玉紅
전금화%장신초%장곤%미옥홍
可溶性致癌抑制因子2%心肌梗死%利钠肽,脑%每搏输出量%心功能评估
可溶性緻癌抑製因子2%心肌梗死%利鈉肽,腦%每搏輸齣量%心功能評估
가용성치암억제인자2%심기경사%리납태,뇌%매박수출량%심공능평고
soluble suppression of tumorigenicity 2%myocardial infarction%natriuretic peptide,brain%stroke volume%cardiac function evaluation
目的：探讨老年急性心肌梗死（AMI）患者血清可溶性致癌抑制因子2（sST2）与其心功能之间关系。方法选取年龄＞60岁、发病24h内的AMI患者59例，来诊后立即测定N端脑钠肽前体（NT-proBNP）、sST2，进行Killip心功能分级，48h内完成超声心动图检查。设立36例年龄匹配的健康对照检测sST2。结果 sST2在AMI组较对照组明显升高[（36.2±21.3） vs （12.5±11.4）μg/L，P＜0.05]；AMI组中sST2和NT-proBNP有明显正相关性（r＝0.585，P＜0.05）；sST2和左心室射血分数（LVEF）表现出明显负相关（r＝-0.611，P＜0.05）；sST2在KillipⅠ级和Ⅱ级[（27.6±14.5） vs （38.0±20.6）μg/L，P＜0.05]，Ⅱ级和Ⅲ+Ⅳ级间差异显著[（56.5±25.0）μg/L， P＜0.05]。结论 AMI患者中sST2较对照组明显升高，且与NT-proBNP和LVEF有相关性，sST2随Killip分级级别升高有上升趋势，而NT-proBNP无此趋势。
目的：探討老年急性心肌梗死（AMI）患者血清可溶性緻癌抑製因子2（sST2）與其心功能之間關繫。方法選取年齡＞60歲、髮病24h內的AMI患者59例，來診後立即測定N耑腦鈉肽前體（NT-proBNP）、sST2，進行Killip心功能分級，48h內完成超聲心動圖檢查。設立36例年齡匹配的健康對照檢測sST2。結果 sST2在AMI組較對照組明顯升高[（36.2±21.3） vs （12.5±11.4）μg/L，P＜0.05]；AMI組中sST2和NT-proBNP有明顯正相關性（r＝0.585，P＜0.05）；sST2和左心室射血分數（LVEF）錶現齣明顯負相關（r＝-0.611，P＜0.05）；sST2在KillipⅠ級和Ⅱ級[（27.6±14.5） vs （38.0±20.6）μg/L，P＜0.05]，Ⅱ級和Ⅲ+Ⅳ級間差異顯著[（56.5±25.0）μg/L， P＜0.05]。結論 AMI患者中sST2較對照組明顯升高，且與NT-proBNP和LVEF有相關性，sST2隨Killip分級級彆升高有上升趨勢，而NT-proBNP無此趨勢。
목적：탐토노년급성심기경사（AMI）환자혈청가용성치암억제인자2（sST2）여기심공능지간관계。방법선취년령＞60세、발병24h내적AMI환자59례，래진후립즉측정N단뇌납태전체（NT-proBNP）、sST2，진행Killip심공능분급，48h내완성초성심동도검사。설립36례년령필배적건강대조검측sST2。결과 sST2재AMI조교대조조명현승고[（36.2±21.3） vs （12.5±11.4）μg/L，P＜0.05]；AMI조중sST2화NT-proBNP유명현정상관성（r＝0.585，P＜0.05）；sST2화좌심실사혈분수（LVEF）표현출명현부상관（r＝-0.611，P＜0.05）；sST2재KillipⅠ급화Ⅱ급[（27.6±14.5） vs （38.0±20.6）μg/L，P＜0.05]，Ⅱ급화Ⅲ+Ⅳ급간차이현저[（56.5±25.0）μg/L， P＜0.05]。결론 AMI환자중sST2교대조조명현승고，차여NT-proBNP화LVEF유상관성，sST2수Killip분급급별승고유상승추세，이NT-proBNP무차추세。
Objective To evaluate the relationship of serum level of soluble suppression of tumorigenicity 2(sST2) with cardiac function in the elderly patients with acute myocardial infarction (AMI). Methods A total of 59 patients (≥60 years) with AMI within 24 h of symptom onset admitted in our department from March to December 2011 were subjected in this study. Immediately after admission, their serum levels of sST2 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured, Killip cardiac function class was analyzed, and echocardiography was performed within 48 h. Another 36 age-matched healthy subjects were recruited as normal controls. Results The serum level of sST2 was significantly higher in AMI patients than in control group [(36.2±21.3) vs (12.5±11.4)μg/L, P<0.05]. In the AMI group, the sST2 level was positively correlated with NT-proBNP level (r=0.585, P<0.05), and negatively correlated with left ventricular ejection fraction (LVEF) (r=-0.611, P<0.05). Significant differences were seen in sST2 level between Killip Ⅰ and Ⅱ [(27.6±14.5) vs (38.0±20.6) μg/L, P<0.05] and between Killip Ⅱ and Ⅲ+Ⅳ [(56.5±25.0)μg/L, P<0.05]. Conclusion The serum level of sST2 is significantly higher in AMI patients than in normal controls. The sST2 level is correlated with NT-proBNP level and LVEF, and also, in an increasing trend with the elevation of Killip grading, but NT-proBNP level has no such trend.
