中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
12期
77-79
,共3页
尿微量白蛋白%胱抑素C%对比剂肾病%经皮冠状动脉介入%心绞痛
尿微量白蛋白%胱抑素C%對比劑腎病%經皮冠狀動脈介入%心絞痛
뇨미량백단백%광억소C%대비제신병%경피관상동맥개입%심교통
Microalbuminuria%CystatinC%Contrast-induced nephropathy%Percutaneous coronary intervention%Angina
目的：探索尿微量白蛋白（MAU）和胱抑素C（CysC）与对比剂肾病（CIN）的相关性。方法：选取2011年1月-2013年6月在本院心血管2科住院接受经皮冠状动脉介入（PCI）治疗的205例心绞痛患者，按照是否发生CIN分为CIN组和非CIN组，所有患者PCI术前和术后3 d监测MAU、CysC和肌酐（Scr）。比较两组PCI前后上述指标的变化，采用logistic回归分析评估MAU、CysC与CIN的相关性。结果：205例患者中共有17例住院期间发生CIN（8.29%）。CIN组的MAU及CysC在24 h内出现变化，48 h开始下降，术后各时间段水平均明显高于术前及非CIN组相应时间的水平（P<0.05）；CIN组Scr水平的变化出现在48 h，48 h和72 h的Scr水平均明显高于术前和非CIN组同一时间的水平（P<0.05）；非CIN组的PCI术前/后MAU、CysC和Scr数值无明显变化（P>0.05）。多因素logistic回归分析校正年龄、性别、贫血、对比剂用量与糖尿病病史，可知PCI术前MAU、CysC水平是CIN的独立预测因子（P<0.05）；对比剂使用量与CIN发生率显著相关（P<0.05）。结论：MAU、CysC的变化能够早期预测CIN发生，MAU、CysC可能是CIN的独立危险因素。
目的：探索尿微量白蛋白（MAU）和胱抑素C（CysC）與對比劑腎病（CIN）的相關性。方法：選取2011年1月-2013年6月在本院心血管2科住院接受經皮冠狀動脈介入（PCI）治療的205例心絞痛患者，按照是否髮生CIN分為CIN組和非CIN組，所有患者PCI術前和術後3 d鑑測MAU、CysC和肌酐（Scr）。比較兩組PCI前後上述指標的變化，採用logistic迴歸分析評估MAU、CysC與CIN的相關性。結果：205例患者中共有17例住院期間髮生CIN（8.29%）。CIN組的MAU及CysC在24 h內齣現變化，48 h開始下降，術後各時間段水平均明顯高于術前及非CIN組相應時間的水平（P<0.05）；CIN組Scr水平的變化齣現在48 h，48 h和72 h的Scr水平均明顯高于術前和非CIN組同一時間的水平（P<0.05）；非CIN組的PCI術前/後MAU、CysC和Scr數值無明顯變化（P>0.05）。多因素logistic迴歸分析校正年齡、性彆、貧血、對比劑用量與糖尿病病史，可知PCI術前MAU、CysC水平是CIN的獨立預測因子（P<0.05）；對比劑使用量與CIN髮生率顯著相關（P<0.05）。結論：MAU、CysC的變化能夠早期預測CIN髮生，MAU、CysC可能是CIN的獨立危險因素。
목적：탐색뇨미량백단백（MAU）화광억소C（CysC）여대비제신병（CIN）적상관성。방법：선취2011년1월-2013년6월재본원심혈관2과주원접수경피관상동맥개입（PCI）치료적205례심교통환자，안조시부발생CIN분위CIN조화비CIN조，소유환자PCI술전화술후3 d감측MAU、CysC화기항（Scr）。비교량조PCI전후상술지표적변화，채용logistic회귀분석평고MAU、CysC여CIN적상관성。결과：205례환자중공유17례주원기간발생CIN（8.29%）。CIN조적MAU급CysC재24 h내출현변화，48 h개시하강，술후각시간단수평균명현고우술전급비CIN조상응시간적수평（P<0.05）；CIN조Scr수평적변화출현재48 h，48 h화72 h적Scr수평균명현고우술전화비CIN조동일시간적수평（P<0.05）；비CIN조적PCI술전/후MAU、CysC화Scr수치무명현변화（P>0.05）。다인소logistic회귀분석교정년령、성별、빈혈、대비제용량여당뇨병병사，가지PCI술전MAU、CysC수평시CIN적독립예측인자（P<0.05）；대비제사용량여CIN발생솔현저상관（P<0.05）。결론：MAU、CysC적변화능구조기예측CIN발생，MAU、CysC가능시CIN적독립위험인소。
Objective:To explore the correlation between microalbuminuria(MAU),cystatinC(CysC)with contrast-induced nephropathy(CIN).Method:205 angina patients underwent percutaneous coronary intervention(PCI) from January 2011 to June 2013 in our hospital were selected,they were randomly divided into CIN group and non CIN group according to the occurrence of CIN.MAU,CysC and Scr of all patients were continuous detected before PCI and within 72 hours after PCI.The changes of above index among two groups were compared.Using logistic regression analysis, the association between MAU,CysC and CIN were assessed.Result:A total of 17 cases occurred CIN(8.29%)during in hospital.In CIN group,MAU and CysC levels changed in 24 hours and reached the peak in 48 h after PCI,it was significantly higher than those before contrast injection in CIN group and those after contrast injection of non-CIN group, respectively(P<0.05).The serum creatinine levels were similar to those before PCI in 24 h and it began to rise in 48 h in CIN group.It had significantly statistics differences in 48 h to 72 h compared with before contrast injection and non-CIN group (P<0.05).There was no significant difference between CysC,MAU and Scr levels before and after PCI at 24,48,72 h in non-CIN group(P>0.05).Multivariate logistic regression analysis,adjusted for age,sex,anemia,the amount of contrast medium and diabetes,display MAU,CysC were independent predictors of CIN(P<0.05).The amount of contrast agent samely associated with incidence of CIN(P<0.05).Conclusion:Changes of MAU,CysC can predict the occurrence of CIN in early stage,MAU,CysC may be the independent risk factors for CIN.
