CAJ | 학술논문

目的探讨肺癌、结缔组织疾病患者血清抗核抗体谱(ANAs)、类风湿因子(RF)的表现特点.方法采用免疫印迹法检测ANAs,免疫散射比浊法检测RF,对照分析90例肺癌患者(均经病理组织学或细胞学检查确诊)、50例结缔组织疾病患者及36例健康人(对照组)血清ANAs、RF的表现特点.结果肺癌组患者ANAs阳性率[46.7％ (42/90)]明显高于对照组[8.3％(3/36)](P＜0.05),70岁以上老年肺癌患者抗核抗体阳性率[64.4％(29/45)]明显高于同年龄段对照组[11.1％ (2/18)](P＜0.05),同时,60岁以上老年肺癌患者ANAs阳性率明显高于60岁以下肺癌患者(P＜0.05).结缔组织疾病患者ANAs阳性率[66.0％ (33/50)]明显高于对照组(P＜0.05),在各年龄组间比较差异无统计学意义(P＞0.05).RF阳性率在肺癌组不同年龄段之间比较,差异均无统计学意义(P＞0.05).结缔组织疾病组RF阳性率[78.0％(39/50)]均高于肺癌组[6.7％(6/90)]和对照组(0％).结论结缔组织疾病患者RF阳性率高于肺癌患者.ANAs不能用于鉴别肺癌及结缔组织疾病,尤其是60岁以上人群.
목적 탐토폐암、결체조직질병환자혈청항핵항체보(ANAs)、류풍습인자(RF)적표현특점.방법 채용면역인적법검측ANAs,면역산사비탁법검측RF,대조분석90례폐암환자(균경병리조직학혹세포학검사학진)、50례결체조직질병환자급36례건강인(대조조)혈청ANAs、RF적표현특점.결과 폐암조환자ANAs양성솔[46.7％ (42/90)]명현고우대조조[8.3％(3/36)](P＜0.05),70세이상노년폐암환자항핵항체양성솔[64.4％(29/45)]명현고우동년령단대조조[11.1％ (2/18)](P＜0.05),동시,60세이상노년폐암환자ANAs양성솔명현고우60세이하폐암환자(P＜0.05).결체조직질병환자ANAs양성솔[66.0％ (33/50)]명현고우대조조(P＜0.05),재각년령조간비교차이무통계학의의(P＞0.05).RF양성솔재폐암조불동년령단지간비교,차이균무통계학의의(P＞0.05).결체조직질병조RF양성솔[78.0％(39/50)]균고우폐암조[6.7％(6/90)]화대조조(0％).결론 결체조직질병환자RF양성솔고우폐암환자.ANAs불능용우감별폐암급결체조직질병,우기시60세이상인군.
Objective To understand the relationship of auto-antibody (include antinuclear antibodies and rheumatoid factor) between lung cancer and connective tissue diseases in eldly people.Methods Western blotting was used to identify the antinuclear antibodies (ANAs),and immunoturibidimetric assay were used to detected rheumatoid factor(RF).The ANAs and RF among 90 cases of lung cancer(diagnosed by pathology or cytology),50 cases of connective tissue diseases and 36 cases of health people were all observed.Results The positive rate of ANAs in lung cancer group[46.7 ％ (42/90)] was significantly different compared with healthy people group [8.3 ％(3/36)],so was it in connective tissue diseases compared with healthy people group; the significant difference of high positive rate of ANAs was present in people older than 60 years old compared with people younger than 60 years.There were no significant difference of ANAs between lung cancer and connective tissue diseases among patients older than 60 years.The positive rate of RF in connective tissue diseases group [78.0％ (39/50)] was significantly different compared with lung cancer [6.7％ (6/90)] and healthy people group(0).Conclusions The positive rate of RF in connective tissue disease is higher than that in lung cancer.ANAs can not be used to differentiate lung cancer from connective tissue diseases,especially in people older than 60 years.