绍兴文理学院学报
紹興文理學院學報
소흥문이학원학보
Journal of Shaoxing University
2012年
7期
9-14
,共6页
苯并二噁茂烷%固体酸%缩合%合成
苯併二噁茂烷%固體痠%縮閤%閤成
분병이오무완%고체산%축합%합성
benzodioxoles%carbon-based solid acid%condensation%catalyzed synthesis
研究了碳基固体酸催化邻苯二酚与环己酮、丁酮、丙酮、丙醛、丁醛、异丁醛、戊醛、异戊醛、正己醛、正辛醛、苯甲醛、二苯甲酮等10余种醛（酮）的合成药物活性中间体的反应.考察了反应时间、酚与醛（酮）的配比、催化剂用量等因素对酚与醛（酮）反应的影响.结果表明,当酚与醛（酮）摩尔比为1∶1.2,催化剂用量为2.5g（1mol）醛（酮）,反应4 h,选择性一般在95%以上,转化率一般也在80%以上,固体酸对邻苯二酚与醛（酮）的反应有较好的催化性能.
研究瞭碳基固體痠催化鄰苯二酚與環己酮、丁酮、丙酮、丙醛、丁醛、異丁醛、戊醛、異戊醛、正己醛、正辛醛、苯甲醛、二苯甲酮等10餘種醛（酮）的閤成藥物活性中間體的反應.攷察瞭反應時間、酚與醛（酮）的配比、催化劑用量等因素對酚與醛（酮）反應的影響.結果錶明,噹酚與醛（酮）摩爾比為1∶1.2,催化劑用量為2.5g（1mol）醛（酮）,反應4 h,選擇性一般在95%以上,轉化率一般也在80%以上,固體痠對鄰苯二酚與醛（酮）的反應有較好的催化性能.
연구료탄기고체산최화린분이분여배기동、정동、병동、병철、정철、이정철、무철、이무철、정기철、정신철、분갑철、이분갑동등10여충철（동）적합성약물활성중간체적반응.고찰료반응시간、분여철（동）적배비、최화제용량등인소대분여철（동）반응적영향.결과표명,당분여철（동）마이비위1∶1.2,최화제용량위2.5g（1mol）철（동）,반응4 h,선택성일반재95%이상,전화솔일반야재80%이상,고체산대린분이분여철（동）적반응유교호적최화성능.
The synthesis of the pharmaceutical intermediates through various aldehydes and ketones and catechol by using solid acid as a catalyst were studied.Effects of reaction time,the mole ratio of reactants and amount of catalyst in the yield of Benzodioxoles were investigated.Results show that solid acid was an effective catalyst for the acetalization and ketalization with high conversion and selectivity in mild conditions.The best reaction condition was as follows：molar ratio of catechol to aldehydes or ketones was 1∶1.2,catalyst amount was 2.5g（1mol）catechol,and the reaction time was 4h.Under that condition,conversion was over 80% and selectivity over 95%.
