湖南师范大学学报（医学版）
湖南師範大學學報（醫學版）
호남사범대학학보（의학판）
JOURNAL OF HUNAN NORMAL UNIVERSITY(MEDICAL SCIENCE)
2013年
1期
51-52,56
,共3页
急性股骨颈骨折%CRP%NSE%MMP-9
急性股骨頸骨摺%CRP%NSE%MMP-9
급성고골경골절%CRP%NSE%MMP-9
acute femoral neck fracture%CRP%NSE%MMP-9
目的：分析急性股骨颈骨折患者血清中超敏C-反应蛋白(CRP)，神经元特异性烯醇化酶(NSE)及血清基质金属蛋白酶-9(MMP-9)的动态变化与疾病严重程度及预后的相关性。方法：选取2011年2月至2012年12月伤后急诊入院的股骨颈骨折患者60例为试验组。以同期门诊体检37例作为健康对照组。分别于发病后24小时以内，3天，7天抽取空腹外周、静脉血检测其CRP、NSE、MMP-9的血清浓度。结果：急性股骨颈骨折患者组患者均明显高于对照组患者，外周血清CRP水平24小时内明显高于受伤7天时和3天时；外周血清NSE水平24小时内和3天时均明显高于7天时；外周血清MMP-9水平在24小时内及3天时均明显高于7天时。结论：三项指标均在受伤早期即升高，半衰期短、下降迅速，因此CRP、NSE、MMP-9血清浓度变化对临床病情的判断，病情转归的预测。对指导治病具有重要的意义。
目的：分析急性股骨頸骨摺患者血清中超敏C-反應蛋白(CRP)，神經元特異性烯醇化酶(NSE)及血清基質金屬蛋白酶-9(MMP-9)的動態變化與疾病嚴重程度及預後的相關性。方法：選取2011年2月至2012年12月傷後急診入院的股骨頸骨摺患者60例為試驗組。以同期門診體檢37例作為健康對照組。分彆于髮病後24小時以內，3天，7天抽取空腹外週、靜脈血檢測其CRP、NSE、MMP-9的血清濃度。結果：急性股骨頸骨摺患者組患者均明顯高于對照組患者，外週血清CRP水平24小時內明顯高于受傷7天時和3天時；外週血清NSE水平24小時內和3天時均明顯高于7天時；外週血清MMP-9水平在24小時內及3天時均明顯高于7天時。結論：三項指標均在受傷早期即升高，半衰期短、下降迅速，因此CRP、NSE、MMP-9血清濃度變化對臨床病情的判斷，病情轉歸的預測。對指導治病具有重要的意義。
목적：분석급성고골경골절환자혈청중초민C-반응단백(CRP)，신경원특이성희순화매(NSE)급혈청기질금속단백매-9(MMP-9)적동태변화여질병엄중정도급예후적상관성。방법：선취2011년2월지2012년12월상후급진입원적고골경골절환자60례위시험조。이동기문진체검37례작위건강대조조。분별우발병후24소시이내，3천，7천추취공복외주、정맥혈검측기CRP、NSE、MMP-9적혈청농도。결과：급성고골경골절환자조환자균명현고우대조조환자，외주혈청CRP수평24소시내명현고우수상7천시화3천시；외주혈청NSE수평24소시내화3천시균명현고우7천시；외주혈청MMP-9수평재24소시내급3천시균명현고우7천시。결론：삼항지표균재수상조기즉승고，반쇠기단、하강신속，인차CRP、NSE、MMP-9혈청농도변화대림상병정적판단，병정전귀적예측。대지도치병구유중요적의의。
Objective Fracture analysis of serum high-sensitivity C-reactive protein in acute femoral neck ( CRP ), neuron specific enolase ( NSE ) and serum matrix metalloproteinase-9 ( MMP-9 ) the dynamic changes of correlation with disease severity and prognosis.Methods 60 patients from 2011 February to 2012 as the test group in December after injury emergency admissions of femoral neck fracture. To the same period 37 cases of outpa-tient medical examination as healthy control group. The difference in incidence after 24 hours, 3 days, 7 days of fasting peripheral, serum concentrations of CRP, NSE, MMP-9. Results Patient groups were significantly higher than the control group of patients with acute femoral neck fracture, the serum levels of CRP within 24 hours was significantly higher than that of the injured 7 days and 3 days;the serum levels of NSE in 24 hours and 3 days were significantly higher than that in 7 days;peripheral serum MMP-9 level in 24 hours and 3 days were signifi-cantly higher than that in 7 days and .Conclusion The three indexes in the injured early rise, short half-life, de-creased rapidly, so the CRP, NSE, MMP-9 serum concentration on clinical judgment, prediction of the outcome of illness. It is of great significance to cure.
