实用医学杂志
實用醫學雜誌
실용의학잡지
THE JOURNAL OF PRACTICAL MEDICINE
2014年
6期
922-924
,共3页
徐辉%汤勇智%郑磊%邹宇聪%刘红伟%林金端%王前
徐輝%湯勇智%鄭磊%鄒宇聰%劉紅偉%林金耑%王前
서휘%탕용지%정뢰%추우총%류홍위%림금단%왕전
骨关节炎%碱性成纤维细胞生长因子%酶联免疫吸附测定
骨關節炎%堿性成纖維細胞生長因子%酶聯免疫吸附測定
골관절염%감성성섬유세포생장인자%매련면역흡부측정
Osteoarthritis%Basic fibroblast growth factor%Enzyme-linked immunosorbent assay
目的:探讨骨关节炎( OA )患者关节滑液和血清中 bFGF ( basic fibroblast growth factor ,碱性成纤维细胞生长因子)与 OA X 线上 Kellgren-Lawrence ( K-L )分级严重程度的相关性。方法:68例经南方医院和清远市人民医院诊断为 OA 的患者纳入本次研究,关节滑液和血清中 bFGF 含量采用 ELISA检测方法,膝骨关节炎影像学严重程度评分采用国际公认的 Kellgren-Lawrence 评分系统。结果:血清和关节滑液 bFGF 水平与骨关节炎影像学分级有显著相关性(r =0.619,P <0.001和 r =0.603,P <0.001),此外血清 bFGF 水平和滑液中 bFGF 水平呈正相关( r =0.688, P <0.001)。结论:血清和关节滑液 bFGF 水平在 OA 患者中显著升高,且与影像学 Kellgren-Lawrence 分级严重程度呈正相关。这表明bFGF 可作为 OA 严重程度的标记物,在 OA 的进展中起到重要作用,为 OA 的临床实验诊断开辟了新的道路。
目的:探討骨關節炎( OA )患者關節滑液和血清中 bFGF ( basic fibroblast growth factor ,堿性成纖維細胞生長因子)與 OA X 線上 Kellgren-Lawrence ( K-L )分級嚴重程度的相關性。方法:68例經南方醫院和清遠市人民醫院診斷為 OA 的患者納入本次研究,關節滑液和血清中 bFGF 含量採用 ELISA檢測方法,膝骨關節炎影像學嚴重程度評分採用國際公認的 Kellgren-Lawrence 評分繫統。結果:血清和關節滑液 bFGF 水平與骨關節炎影像學分級有顯著相關性(r =0.619,P <0.001和 r =0.603,P <0.001),此外血清 bFGF 水平和滑液中 bFGF 水平呈正相關( r =0.688, P <0.001)。結論:血清和關節滑液 bFGF 水平在 OA 患者中顯著升高,且與影像學 Kellgren-Lawrence 分級嚴重程度呈正相關。這錶明bFGF 可作為 OA 嚴重程度的標記物,在 OA 的進展中起到重要作用,為 OA 的臨床實驗診斷開闢瞭新的道路。
목적:탐토골관절염( OA )환자관절활액화혈청중 bFGF ( basic fibroblast growth factor ,감성성섬유세포생장인자)여 OA X 선상 Kellgren-Lawrence ( K-L )분급엄중정도적상관성。방법:68례경남방의원화청원시인민의원진단위 OA 적환자납입본차연구,관절활액화혈청중 bFGF 함량채용 ELISA검측방법,슬골관절염영상학엄중정도평분채용국제공인적 Kellgren-Lawrence 평분계통。결과:혈청화관절활액 bFGF 수평여골관절염영상학분급유현저상관성(r =0.619,P <0.001화 r =0.603,P <0.001),차외혈청 bFGF 수평화활액중 bFGF 수평정정상관( r =0.688, P <0.001)。결론:혈청화관절활액 bFGF 수평재 OA 환자중현저승고,차여영상학 Kellgren-Lawrence 분급엄중정도정정상관。저표명bFGF 가작위 OA 엄중정도적표기물,재 OA 적진전중기도중요작용,위 OA 적림상실험진단개벽료신적도로。
Objective To explore the correlationship between level of bFGF (basic fibroblast growth factor) in serum and synovia and X-ray severity (Kellgren-Lawrence Grading System) in patients with knee OA. Method 68 patients with knee OA were enrolled into this study. Knee OA grading was evaluated according to the Kellgren-Lawrence classification. bFGF levels in both serum and synovia were examined using enzyme-linked immunosorbent assay. Results The level of bFGF in serum and synovial fluid in patients with knee OA were positively correlated with radiographic severity (r = 0.619, P < 0.001 and r = 0.603, P < 0.001, respectively). Further analysis revealed that there was a positive correlation between the level of bFGF in serum and in synovia fluid (r = 0.688, P < 0.001). Conclusions Levels of bFGF in serum and synovial fluid were significantly increased in patients with OA, and levels of bFGF were positively correlated with radiographic severity. These findings indicate that bFGF levels may be a biomarker of disease severity and could play an crucial part in the pathophysiology of degenerative process in OA.