CAJ | 학술논문

背景烟草危害是当今世界最严重的公共卫生问题之一.目前我国约有吸烟者3.5亿,占全球吸烟总人数的1/3,其中成年男性吸烟率为66.0％,女性为3.08％.吸烟成瘾实质上就是尼古丁依赖,尼古丁依赖患者罹患各种慢性疼痛疾病的比例增高.临床和动物实验发现尼古丁具有镇痛作用. 目的了解尼古丁具有镇痛作用的神经生物学机制及其研究进展.内容尼古丁镇痛作用是通过乙酰胆碱受体(nAChRs)介导的,作用于α4β2AChR受体通过脊髓上机制发挥镇痛作用；作用于α7 nAChR通过胆碱能抗炎反射,进而影响小胶质细胞的迁移、增殖和活化等来发挥镇痛作用. 趋向研究尼古丁镇痛作用和尼古丁依赖戒断后机体疼痛生理的变化机制,为吸烟患者的疼痛治疗研究奠定基础.
배경 연초위해시당금세계최엄중적공공위생문제지일.목전아국약유흡연자3.5억,점전구흡연총인수적1/3,기중성년남성흡연솔위66.0％,녀성위3.08％.흡연성은실질상취시니고정의뢰,니고정의뢰환자리환각충만성동통질병적비례증고.림상화동물실험발현니고정구유진통작용. 목적 료해니고정구유진통작용적신경생물학궤제급기연구진전.내용 니고정진통작용시통과을선담감수체(nAChRs)개도적,작용우α4β2AChR수체통과척수상궤제발휘진통작용；작용우α7 nAChR통과담감능항염반사,진이영향소효질세포적천이、증식화활화등래발휘진통작용. 추향 연구니고정진통작용화니고정의뢰계단후궤체동통생리적변화궤제,위흡연환자적동통치료연구전정기출.
Background The danger of tobacco is one of the world's most serious public health problem.At present there are about 350 million smokers in China,accounting for 1/3 of the total smokers worldwide,in which adult male smoking rate is 66.0％,3.08％ for women.Tobacco addiction is essentially nicotine dependence.Nicotine dependence increases the proportion of patients suffering from chronic pain diseases.Clinical and animal studies found that nicotine has analgesic effects.Objective To understand the neurobiological mechanisms of analgesic effects of nicotine and their research progress.Content Analgesic effects of nicotine are mediated by nAChR,α4β2 nAChRs play analgesic effects by supraspinal mechanisms,α7 nAChRs play a role in cholinergic anti-inflammatory reflection,thereby affecting migration,proliferation and activation of microglia,then play an analgesic effect.Trend Studying on analgesic effects of nicotine and the change s of physiological mechanisms in pain after nicotine dependence-abstinence lays the Foundation for research on treatment of pain in patients with smoking.