CAJ | 학술논문

泛素-蛋白酶体途径是细胞内蛋白质降解的主要途径，在多种细胞生命过程中发挥重要作用。目前研究证实慢性酒精中毒可导致泛素-蛋白酶体途径异常调节，主要涉及蛋白酶体活性、泛素分子合成以及相关蛋白分子表达改变等，并且与一些慢性酒精中毒性疾病的发生有关，包括酒精中毒性肝病、酒精中毒性脑病和酒精中毒性肌病。这些发现为进一步揭示酒精诱导损伤的分子机制以及研发治疗慢性酒精中毒性疾病的新型药物提供了重要的研究方向。
범소-단백매체도경시세포내단백질강해적주요도경，재다충세포생명과정중발휘중요작용。목전연구증실만성주정중독가도치범소-단백매체도경이상조절，주요섭급단백매체활성、범소분자합성이급상관단백분자표체개변등，병차여일사만성주정중독성질병적발생유관，포괄주정중독성간병、주정중독성뇌병화주정중독성기병。저사발현위진일보게시주정유도손상적분자궤제이급연발치료만성주정중독성질병적신형약물제공료중요적연구방향。
Ubiquitin-proteasome pathway is the main way for intracellular protein degradation and plays an important role in a variety of cellular processes.Studies have confirmed that chronic alcoholism leads to abnormal regulation of ubiquitin-proteasome pathway involving alterations of proteasome activity,ubiquitin synthesis and related protein expression.Moreover,the abnormal regulation of ubiquitin-proteasome pathway is correlated with the pathogenesis of chronic alcohol-ic diseases,including alcoholic liver disease,alcoholic encephalopathy and alcoholic myopathy. These findings provide an important research direction for further revealing the molecular mecha-nisms of alcohol-induced tissue inj uries and developing new drugs for the treatment of chronic al-coholic diseases.