中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
7期
1019-1020,1021
,共3页
结直肠外科手术%结直肠肿瘤%胰岛素样生长因子Ⅰ%血管内皮生长因子
結直腸外科手術%結直腸腫瘤%胰島素樣生長因子Ⅰ%血管內皮生長因子
결직장외과수술%결직장종류%이도소양생장인자Ⅰ%혈관내피생장인자
Colorectal surgery%Colorectal neoplasms%Insulin-like growth factor-1%Vascular endothelial growth factor
目的：探讨Ⅰ期切除吻合术对左半结肠癌急性肠梗阻患者血清胰岛素样生长因子-1（ IGF-1）和血管内皮生长因子（ VEGF）的影响。方法92例左半结肠癌急性肠梗阻患者按数字表法随机分为观察组46例、对照组46例，观察组采用Ⅰ期切除吻合术，对照组采用Hartman术，术前、术后测定两组患者血清IGF-1和VEGF的表达。结果观察组住院时间为（14．9±6．4）d，短于对照组的（28．3±9．6）d（t＝5．426，P＜0.05）；观察组切口感染、吻合口瘘分别为2例、1例，对照组分别为3例、1例，两组差异均无统计学意义（χ2＝2.19、1．29，均P＞0．05）；两组术后血清IGF-1和VEGF均明显降低，与对照组比较，观察组降低更明显（ t＝3.064、2．394，均P＜0．05）。结论Ⅰ期切除吻合术可以明显减少左半结肠癌急性肠梗阻患者血清IGF-1和VEGF的表达。
目的：探討Ⅰ期切除吻閤術對左半結腸癌急性腸梗阻患者血清胰島素樣生長因子-1（ IGF-1）和血管內皮生長因子（ VEGF）的影響。方法92例左半結腸癌急性腸梗阻患者按數字錶法隨機分為觀察組46例、對照組46例，觀察組採用Ⅰ期切除吻閤術，對照組採用Hartman術，術前、術後測定兩組患者血清IGF-1和VEGF的錶達。結果觀察組住院時間為（14．9±6．4）d，短于對照組的（28．3±9．6）d（t＝5．426，P＜0.05）；觀察組切口感染、吻閤口瘺分彆為2例、1例，對照組分彆為3例、1例，兩組差異均無統計學意義（χ2＝2.19、1．29，均P＞0．05）；兩組術後血清IGF-1和VEGF均明顯降低，與對照組比較，觀察組降低更明顯（ t＝3.064、2．394，均P＜0．05）。結論Ⅰ期切除吻閤術可以明顯減少左半結腸癌急性腸梗阻患者血清IGF-1和VEGF的錶達。
목적：탐토Ⅰ기절제문합술대좌반결장암급성장경조환자혈청이도소양생장인자-1（ IGF-1）화혈관내피생장인자（ VEGF）적영향。방법92례좌반결장암급성장경조환자안수자표법수궤분위관찰조46례、대조조46례，관찰조채용Ⅰ기절제문합술，대조조채용Hartman술，술전、술후측정량조환자혈청IGF-1화VEGF적표체。결과관찰조주원시간위（14．9±6．4）d，단우대조조적（28．3±9．6）d（t＝5．426，P＜0.05）；관찰조절구감염、문합구루분별위2례、1례，대조조분별위3례、1례，량조차이균무통계학의의（χ2＝2.19、1．29，균P＞0．05）；량조술후혈청IGF-1화VEGF균명현강저，여대조조비교，관찰조강저경명현（ t＝3.064、2．394，균P＜0．05）。결론Ⅰ기절제문합술가이명현감소좌반결장암급성장경조환자혈청IGF-1화VEGF적표체。
Objective To study the effectiveness of phase Ⅰleft colon resection and anastomosis on serum insulin-like growth factor-1(IGF-1) and vascular endothelial growth factor (VEGF) in patients with acute intestinal obstruction.Methods 92 patients with acute intestinal obstruction were randomly divided into two groups ,the obser-vation group(n=46) and the control group(n=46).The patients in the observation group were operated through phase Ⅰleft colon resection and anastomosis ,while the patients in the control group were operated through Hartman . Serum IGF-1 and VEGF were measured in preoperative and postoperative patients .Results The observation group for the length of time (14.9 ±6.4)d,shorter than the control group(28.3 ±9.6)d(t=5.426,P<0.05);observation group,incision infection,anastomotic leakage were 2 cases,1 cases,the control group was 3 cases,1 cases,no signifi-cant difference between two groups (χ2 =2.19,1.29,all P>0.05);two groups of postoperative serum levels of IGF-1 and VEGF were significantly decreased ,compared with the control group ,the observation group was significantly lower (t=3.064,2.394,all P<0.05).Conclusion Phase Ⅰ left colon resection and anastomosis can significantly de-crease serum IGF-1 and VEGF levels in patients with acute intestinal obstruction .
