CAJ | 학술논문

以二乙烯三胺和乙酸为原料,通过成环、催化脱氢和水解三步反应合成了1-氨乙基-2-甲基咪唑。通过红外光谱、核磁共振氢谱和质谱对合成物进行了表征。结果表明：在n（二乙烯三胺）∶n（乙酸）=1∶2,升温至200℃关环脱水的条件下,生成N-（2-甲基-2-咪唑啉）乙基乙酰胺,达到92.3%的产率。然后,将该咪唑啉用雷尼镍催化脱氢生成对应的咪唑,产率94.0%。最后,将N-（2-甲基-2-咪唑）乙基乙酰胺用盐酸回流水解,得到的1-氨乙基-2-甲基咪唑,产率84.8%。
이이을희삼알화을산위원료,통과성배、최화탈경화수해삼보반응합성료1-안을기-2-갑기미서。통과홍외광보、핵자공진경보화질보대합성물진행료표정。결과표명：재n（이을희삼알）∶n（을산）=1∶2,승온지200℃관배탈수적조건하,생성N-（2-갑기-2-미서람）을기을선알,체도92.3%적산솔。연후,장해미서람용뢰니얼최화탈경생성대응적미서,산솔94.0%。최후,장N-（2-갑기-2-미서）을기을선알용염산회류수해,득도적1-안을기-2-갑기미서,산솔84.8%。
1-Aminoethyl-2-methylimidazole was synthesized from diethylenetriamine and acetic acid by cyclization,catalytic dehydration and hydrolysis reaction.The chemical struction was characterized by FT-IR,1H-NMR and MS.The experiment showed that when n(diethylenetriamine)∶n(acetic acid)=1∶2,elevating temperature to 200 ℃,the product was N-(2-methyl-2-imidazolinyl)ethyl acetamide with the yield of 92.3 %.The next reaction was dehydration of imidazoline to imidazole with Raney-Ni.The yield of this reaction was 94.0 %.Finally,1-Aminoethyl-2-methylimidazole could be got by hydrolysis reaction of N-(2-methyl-2-imidazolyl)ethyl acetamide with HCL and the yield was 84.8 %.