CAJ | 학술논문

磺酰脲类化合物具有很高的生物活性，在医药和农药上有非常广泛的应用，5-氰基糖精是制备5-取代糖精洐行物和5-取代苯磺酰脲类化合物的重要中间体。文章以对甲苯腈为原料，经氯磺化、氨解、氧化得到5-氰基糖精，总收率43.3%；产物及中间体经IR，^1HNMR，MS确证结构。
광선뇨류화합물구유흔고적생물활성，재의약화농약상유비상엄범적응용，5-청기당정시제비5-취대당정행행물화5-취대분광선뇨류화합물적중요중간체。문장이대갑분정위원료，경록광화、안해、양화득도5-청기당정，총수솔43.3%；산물급중간체경IR，^1HNMR，MS학증결구。
Sulfonylurea compound is widely applied in medicine and pesticide for its high biological activity. 5-Cyanosaccharin is an important intermediate for preparing 5-substituted saccharin derivatives and 5-substituted benzosulfonylurea compounds. In the paper, 5-cyanosaccharin was prepared from p-tolunitrile by chlorosulfonation, amoniation, oxidation reaction in total yield of 43.3 %. Product and intermdiates were confirmed by IR, ^1H NMR and MS.