中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
3期
243-245
,共3页
杨丽萍%鞠海兵%陈宗宁%赵渊%赵谷天
楊麗萍%鞠海兵%陳宗寧%趙淵%趙穀天
양려평%국해병%진종저%조연%조곡천
2型糖尿病%糖化血红蛋白%高原地区
2型糖尿病%糖化血紅蛋白%高原地區
2형당뇨병%당화혈홍단백%고원지구
Type 2 diabetes mellitus%Glycosylated hemoglobin%Plateau
目的 探讨高原状态下2型糖尿病患者糖化血红蛋白(HbA1c)与空腹血糖、餐后2h血糖、血红蛋白的相关关系,了解HbA1c的影响因素及血红蛋白变化对血糖和HbA1c的影响.方法 选择居住在丽江市(海拔2420 m)5年以上且用药治疗3个月以上未做调整的2型糖尿病患者101例,静脉采血测定空腹血糖、餐后2h血糖,同时测定HbA1c和血红蛋白,对HbA1c与空腹血糖、餐后2h血糖、血红蛋白进行散点图、Pearson相关分析及回归分析；对高血红蛋白组和正常血红蛋白组之间的空腹血糖、餐后2h血糖、HbA1c进行比较.结果 HbA1c与空腹血糖、餐后2h血糖呈正相关,相关系数分别为0.82(P ＜0.001)和0.29 (P=0.003),HbA1c与空腹血糖和餐后2h血糖的回归方程为Y=2.674+0.52X1 +0.018X2；HbA1c与血红蛋白无明显相关(r=-0.06,P=0.551).不同浓度的血红蛋白组之间空腹血糖、餐后2h血糖、HbA1c比较差异均无统计学意义(P均＞0.05).结论 影响HbA1c的主要因素是空腹血糖和餐后2h血糖,血红蛋白对空腹、餐后2h血糖和HbA1c无明显影响.
目的 探討高原狀態下2型糖尿病患者糖化血紅蛋白(HbA1c)與空腹血糖、餐後2h血糖、血紅蛋白的相關關繫,瞭解HbA1c的影響因素及血紅蛋白變化對血糖和HbA1c的影響.方法 選擇居住在麗江市(海拔2420 m)5年以上且用藥治療3箇月以上未做調整的2型糖尿病患者101例,靜脈採血測定空腹血糖、餐後2h血糖,同時測定HbA1c和血紅蛋白,對HbA1c與空腹血糖、餐後2h血糖、血紅蛋白進行散點圖、Pearson相關分析及迴歸分析；對高血紅蛋白組和正常血紅蛋白組之間的空腹血糖、餐後2h血糖、HbA1c進行比較.結果 HbA1c與空腹血糖、餐後2h血糖呈正相關,相關繫數分彆為0.82(P ＜0.001)和0.29 (P=0.003),HbA1c與空腹血糖和餐後2h血糖的迴歸方程為Y=2.674+0.52X1 +0.018X2；HbA1c與血紅蛋白無明顯相關(r=-0.06,P=0.551).不同濃度的血紅蛋白組之間空腹血糖、餐後2h血糖、HbA1c比較差異均無統計學意義(P均＞0.05).結論 影響HbA1c的主要因素是空腹血糖和餐後2h血糖,血紅蛋白對空腹、餐後2h血糖和HbA1c無明顯影響.
목적 탐토고원상태하2형당뇨병환자당화혈홍단백(HbA1c)여공복혈당、찬후2h혈당、혈홍단백적상관관계,료해HbA1c적영향인소급혈홍단백변화대혈당화HbA1c적영향.방법 선택거주재려강시(해발2420 m)5년이상차용약치료3개월이상미주조정적2형당뇨병환자101례,정맥채혈측정공복혈당、찬후2h혈당,동시측정HbA1c화혈홍단백,대HbA1c여공복혈당、찬후2h혈당、혈홍단백진행산점도、Pearson상관분석급회귀분석；대고혈홍단백조화정상혈홍단백조지간적공복혈당、찬후2h혈당、HbA1c진행비교.결과 HbA1c여공복혈당、찬후2h혈당정정상관,상관계수분별위0.82(P ＜0.001)화0.29 (P=0.003),HbA1c여공복혈당화찬후2h혈당적회귀방정위Y=2.674+0.52X1 +0.018X2；HbA1c여혈홍단백무명현상관(r=-0.06,P=0.551).불동농도적혈홍단백조지간공복혈당、찬후2h혈당、HbA1c비교차이균무통계학의의(P균＞0.05).결론 영향HbA1c적주요인소시공복혈당화찬후2h혈당,혈홍단백대공복、찬후2h혈당화HbA1c무명현영향.
Objective To explore the correlation between glycosylated hemoglobin(HbA1c) level and hemoglobin(Hb),fasting blood glucose (FBG),two-hour postmeal blood glucose (PBG2h) levels in type 2 diabetic patients on plateau.To evaluate influencing factors of HbA1c and effects of Hb level on HbA1c and blood glucose levels.Methods A total of 101 type 2 diabetic patients with no change antidiabetic treatment above 3 months and living in Lijiang city(at altitude 2420 m) above 5 years were investigated.The mean value of FBG,PBG2h,HbA1c and Hb were determined.The correlation between HbA1c and Hb,FBG,PBG2h were studied by scatter diagram,Pearson correlation analysis and the regression analysis.HbA1c,FBG,PBG2h levels were compared between high hemoglobin group and normal hemoglobin group.Results The HbA1c level was positively correlated with the FBG (r =0.82,P ＜ 0.001) and the PBG2h (r =0.29,P =0.003) levels.The regression equation between HbA1c and FBG,PBG2h was Y =2.674 + 0.52X1 + 0.018X2.There was no correlation in HbA1c and Hb level(r =-0.06,P =0.551).There was no difference on HbA1c,FBG,PBG2h levels between high hemoglobin group and normal hemoglobin group (P ＞ 0.05).Conclusion The major influencing factors of HbAlc are FBG and PBG2h.The hemoglobin level has no obvious effects on HbA1c and blood glucose levels.
