CAJ | 학술논문

背景吸入麻醉药已在临床广泛应用,但其作用机理至今尚未明确.而缝隙连接(gap junctions,GJ)也是神经系统介导细胞间信息传递的重要方式,可能是吸入全麻药作用的分子靶位之一. 目的分析推测GJ及其介导的细胞间传递是否参与吸入全麻药的麻醉作用. 内容阐述吸入麻醉药的机制,GJ在中枢神经系统中的结构、分布、功能以及与吸入麻醉药作用的关系. 趋向研究GJ及其介导的细胞间传递能为今后研究全麻药的作用机制提供新方向.
배경 흡입마취약이재림상엄범응용,단기작용궤리지금상미명학.이봉극련접(gap junctions,GJ)야시신경계통개도세포간신식전체적중요방식,가능시흡입전마약작용적분자파위지일. 목적 분석추측GJ급기개도적세포간전체시부삼여흡입전마약적마취작용. 내용 천술흡입마취약적궤제,GJ재중추신경계통중적결구、분포、공능이급여흡입마취약작용적관계. 추향 연구GJ급기개도적세포간전체능위금후연구전마약적작용궤제제공신방향.
Background Inhalational anesthetics have been widely used in clinical anesthesia for a wide range of surgeries.But the mechanism of anesthetic actions is still not clear.Gap junctions (GJ) are important ways of information delivery among mediate cells in nervous system.Perhaps it is one of the molecular sites of inhalational anesthetic action.Objective The purpose of this article is to investigate whether GJ and GJ mediated intercellular communication may participate in the mechanism of action of inhalational anesthetics or not.Content The mechanism of action of inhalational anesthetics has been analyzed.Moreover,the structure,distribution and function of GJ and its relationship with inhalational anesthetics in the central nervous system were also described.Trend The research about GJ and the intercellular communication mediated by GJ is a new direction to explore the anesthetic mechanism.