CAJ | 학술논문

探讨卡马西平对尿毒症性周围神经病变的治疗作用。选择45例确诊尿毒症性周围神经病变的维持性血液透析尿毒症患者,随机分为治疗组（n=23）和对照组（n=22）,分别给予卡马西平（100mg,每日3次）和安慰剂治疗8周;两组患者均每周行3次常规血液透析治疗。治疗前、治疗4周、治疗8周时分别观察两组患者周围神经病变的临床症状及正中神经、胫神经、腓总神经的感觉神经传导速度（SCV）.治疗8周后,对照组患者周围神经病变的临床症状及感觉神经传导速度无明显改善。而治疗组患者周围神经病变的临床症状及感觉神经传导速度较治疗前有明显改善,其程度显著优于对照组（P〈0.05）.卡马西平能有效地改善尿毒症性周围神经病变。
탐토잡마서평대뇨독증성주위신경병변적치료작용。선택45례학진뇨독증성주위신경병변적유지성혈액투석뇨독증환자,수궤분위치료조（n=23）화대조조（n=22）,분별급여잡마서평（100mg,매일3차）화안위제치료8주;량조환자균매주행3차상규혈액투석치료。치료전、치료4주、치료8주시분별관찰량조환자주위신경병변적림상증상급정중신경、경신경、비총신경적감각신경전도속도（SCV）.치료8주후,대조조환자주위신경병변적림상증상급감각신경전도속도무명현개선。이치료조환자주위신경병변적림상증상급감각신경전도속도교치료전유명현개선,기정도현저우우대조조（P〈0.05）.잡마서평능유효지개선뇨독증성주위신경병변。
Objective To evaluate the effect of carbamazepine in treatment of uremic peripheral nervous lesion.Methods Forty-five patients with uremic peripheral nervous lesion were selected and randomly divided into therapy group(n=23) and control group(n=22),receive respectively carbamazepine(100mg three times a day) and placebo treatment for eight weeks.All patients received regular hemodialysis thrice a week.The clinical symptoms and the sensory conduction velocity(SCV) of median nerve,tibial nerve and lateral popliteal nerve were measured in each group before,four weeks and eight weeks cost treatment respectively.Results After eight weeks treatment,the clinical symptoms,the nerve reflex and the SCV showed no obviously difference in control group,but significantly improvement in therapy group(P0.05).Conclusion Carbamazepine are effective for patients with uremic peripheral nervous lesion.