CAJ | 학술논문

常规静电纺丝法制得的丝素蛋白纤维毡的力学性能较差,不能很好地满足人体对生物组织工程支架的要求。为了提高丝素蛋白组织工程支架的力学性能,对丝素蛋白纤维毡进行增强改性是目前研究的热点。文章简要介绍了丝素蛋白的结构和性能及其在组织工程领域的应用研究,重点总结了提高静电纺丝素蛋白纤维毡力学性能的3种方法,即后处理、添加增强组分以及制备取向纳米纤维。
상규정전방사법제득적사소단백섬유전적역학성능교차,불능흔호지만족인체대생물조직공정지가적요구。위료제고사소단백조직공정지가적역학성능,대사소단백섬유전진행증강개성시목전연구적열점。문장간요개소료사소단백적결구화성능급기재조직공정영역적응용연구,중점총결료제고정전방사소단백섬유전역학성능적3충방법,즉후처리、첨가증강조분이급제비취향납미섬유。
Traditional electrospun silk fibroin (SF) mats normally show poor mechanical properties and limit the application of SF in tissue engineering. In order to improve the mechanical properties, people paid great attentions to modify the electrospun SF mats recently. This review introduced the structures and properties of SF as well as the applications of electrospun SF mats in tissue engineering. Three main reinforcement methods for SF mats were summarized in detail, such as post-treatment, addition of reinforcing agent and alignment of nanofibers.