CAJ | 학술논문

目的：探讨生精中药方剂对男性不育患者精液参数及精浆一氧化氮（NO）、一氧化氮合酶（NOS）、总抗氧化能力（T-AOC）的作用，为临床男性不育的治疗提供依据。方法将70例男性不育患者分为实验组和对照组，对照组给予维生素E、多元维生素片治疗；实验组在对照组的基础上加用生精中药方剂治疗，疗程为3个月，分别搜集其治疗前后的精液标本，对其进行精液分析，并测量精浆中NO 、NOS、T-AOC的变化。结果实验组治疗前后，精子密度、精子活动率、T-AOC明显升高，均具有统计学意义（P＜0.05）；NO、NOS相比有升高趋势，但无统计学意义（P ＞0.05）；正常形态精子比例相比无明显差异（P ＞0.05）。对照组治疗前后精子密度、活动率、正常形态精子比例、NO、NOS、T-AOC均无明显差异（P＞0.05）。结论生精中药方剂能明显改善男性不育患者的精液质量，其主要是通过抗氧化升高T-AOC起作用的。
목적：탐토생정중약방제대남성불육환자정액삼수급정장일양화담（NO）、일양화담합매（NOS）、총항양화능력（T-AOC）적작용，위림상남성불육적치료제공의거。방법장70례남성불육환자분위실험조화대조조，대조조급여유생소E、다원유생소편치료；실험조재대조조적기출상가용생정중약방제치료，료정위3개월，분별수집기치료전후적정액표본，대기진행정액분석，병측량정장중NO 、NOS、T-AOC적변화。결과실험조치료전후，정자밀도、정자활동솔、T-AOC명현승고，균구유통계학의의（P＜0.05）；NO、NOS상비유승고추세，단무통계학의의（P ＞0.05）；정상형태정자비례상비무명현차이（P ＞0.05）。대조조치료전후정자밀도、활동솔、정상형태정자비례、NO、NOS、T-AOC균무명현차이（P＞0.05）。결론생정중약방제능명현개선남성불육환자적정액질량，기주요시통과항양화승고T-AOC기작용적。
Objective To investigate the effects of Chinese herbs on the spermatogenic function of male infertile patients and its mechanism. Methods Total of 70 patients were divided into two groups such as the treatment group and the control group. The patients in the control group were treated with Vit E and multivitamin, and the patients in the treatment group with Vit E and multivitamin combining with Chinese herbs. Period of treatment lasted three months. Semen samples of pre- and post-treatment were collected, and the levels of NO, NOS and T-AOC were measured. Results After treatment, sperm concentration, motility, and T-AOC level were all increased in the treatment group, which showed a statistical significance(P<0.05), while NO and NOS were also increased, but no statistical significance(P>0.05). There were no statistical significances in sperm concentration, motility, NO level, NOS level and T-AOC level in the control group. Conclusion Chinese herbs can improve the sperm quality greatly, which may be associated with T-AOC increase.