中国男科学杂志
中國男科學雜誌
중국남과학잡지
CHINESE JOURNAL OF ANDROLOGY
2013年
12期
26-28
,共3页
闫涛%陈光耀%井元恒%陈跃英%翁旭东
閆濤%陳光耀%井元恆%陳躍英%翁旭東
염도%진광요%정원항%진약영%옹욱동
精索静脉曲张%性腺甾类激素%精液%不育, 男性
精索靜脈麯張%性腺甾類激素%精液%不育, 男性
정색정맥곡장%성선치류격소%정액%불육, 남성
varicocele%gonadal steroid hormones%semen parameters%infertility,male
目的：探讨精索静脉曲张（VC）患者血清性激素变化及对生育功能的影响。方法回顾分析2010年8月至2013年5月在我院就治的76例VC患者，根据患者是否具有生育能力，分为生育组（A组，n=41），年龄27±2.05（22~39岁），不育组（B组，n=35），年龄28±3.17（20~41）岁。有生育功能的正常志愿者为对照组（C组，n=30），年龄28±2.35（23~38）岁。采用ELISA双抗体夹心法测定各组患者血清性激素，计算机辅助精液分析（CASA）比较各组精液参数。结果精索静脉曲张不育组精子密度、精子活力、血清抑制素B（InhB）显著低于正常对照组和生育组（P ＜0.05），畸形精子、血清卵泡刺激素（FSH）显著高于正常对照组和生育组（P＜0.05），血清黄体生成素（LH）显著高于生育组，精浆量、血清睾酮（T）与生育组和正常对照组比较无统计学意义（P＞0.05）；VC生育组精子密度显著高于正常对照组（P＜0.05），其他精液参数和血清FSH、InhB、LH、T与正常对照组比较无统计学意义（P＞0.05）。结论精索静脉曲张不育患者血清性激素水平明显发生异常，对患者的生育功能产生显著影响。
目的：探討精索靜脈麯張（VC）患者血清性激素變化及對生育功能的影響。方法迴顧分析2010年8月至2013年5月在我院就治的76例VC患者，根據患者是否具有生育能力，分為生育組（A組，n=41），年齡27±2.05（22~39歲），不育組（B組，n=35），年齡28±3.17（20~41）歲。有生育功能的正常誌願者為對照組（C組，n=30），年齡28±2.35（23~38）歲。採用ELISA雙抗體夾心法測定各組患者血清性激素，計算機輔助精液分析（CASA）比較各組精液參數。結果精索靜脈麯張不育組精子密度、精子活力、血清抑製素B（InhB）顯著低于正常對照組和生育組（P ＜0.05），畸形精子、血清卵泡刺激素（FSH）顯著高于正常對照組和生育組（P＜0.05），血清黃體生成素（LH）顯著高于生育組，精漿量、血清睪酮（T）與生育組和正常對照組比較無統計學意義（P＞0.05）；VC生育組精子密度顯著高于正常對照組（P＜0.05），其他精液參數和血清FSH、InhB、LH、T與正常對照組比較無統計學意義（P＞0.05）。結論精索靜脈麯張不育患者血清性激素水平明顯髮生異常，對患者的生育功能產生顯著影響。
목적：탐토정색정맥곡장（VC）환자혈청성격소변화급대생육공능적영향。방법회고분석2010년8월지2013년5월재아원취치적76례VC환자，근거환자시부구유생육능력，분위생육조（A조，n=41），년령27±2.05（22~39세），불육조（B조，n=35），년령28±3.17（20~41）세。유생육공능적정상지원자위대조조（C조，n=30），년령28±2.35（23~38）세。채용ELISA쌍항체협심법측정각조환자혈청성격소，계산궤보조정액분석（CASA）비교각조정액삼수。결과정색정맥곡장불육조정자밀도、정자활력、혈청억제소B（InhB）현저저우정상대조조화생육조（P ＜0.05），기형정자、혈청란포자격소（FSH）현저고우정상대조조화생육조（P＜0.05），혈청황체생성소（LH）현저고우생육조，정장량、혈청고동（T）여생육조화정상대조조비교무통계학의의（P＞0.05）；VC생육조정자밀도현저고우정상대조조（P＜0.05），기타정액삼수화혈청FSH、InhB、LH、T여정상대조조비교무통계학의의（P＞0.05）。결론정색정맥곡장불육환자혈청성격소수평명현발생이상，대환자적생육공능산생현저영향。
Objective To investigate the changes of sexual hormones in patients with varicocele and explore its effect on fertility. Methods Clinical data of 76 patients with varicocele in our hospital from August 2010 to May 2013 were retrospectively analyzed. According to reproductive function status, they were divided into two groups such as fertility group (A, n = 41, aged 27 ± 2.05 years old), infertility group (B, n = 35, aged 28 ± 3.17 years old). The volunteers with normal reproductive function were defined as the control group (C group, n = 30), aged 28 ± 2.35 (23~38 years old). The levels of serum sex hormones were detected by ELISA, and semen parameters were determined by computer-aided sperm analysis (CASA). Results Sperm concentration, sperm motility, plasma InhB in the infertile group were significantly lower than those in the control group and the fertile group (P<0.05), whereas abnormal sperm, plasma FSH were significantly higher than those in the control group and the fertile group (P<0.05) , the level of LH was significantly higher than that in fertile group, seminal volume, plasma T compared with the fertility group and the normal control group was not statistically significant (P>0.05); Sperm density in the fertile group was significantly higher than that in the normal control group (P <0.05), other semen parameters and plasma FSH, InhB, LH, T compared with the normal control group was not statistically significant (P>0.05). Conclusion The level of serum sex hormone in infertile patients with varicocele was significantly abnormal, resulting in a significant impact onpatients’ reproductive function.
