国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2013年
4期
375-378
,共4页
保护素D1%炎症%脂质介质%炎症消退
保護素D1%炎癥%脂質介質%炎癥消退
보호소D1%염증%지질개질%염증소퇴
Protectin D1%Inflammatory%Lipid mediator%Inflammation resolution
背景 保护素D1 (protectin D1,PD1)是近期发现的由二十二碳六烯酸(docosahexenoic acid,DHA)衍生的生物活性分子,是机体一种重要的内源性脂质抗炎及促炎症消退介质. 目的 深入认识这个新的家族有助于探讨多种疾病的发病机制,并为其治疗提供新的靶点. 内容 大量研究表明,PD1对多种炎性细胞的功能和多种炎症相关基因的表达有广泛的调节作用,能促进炎症反应及时消退,可改善多种疾病的转归.现就PD1的生物学活性、对炎性细胞及炎症相关疾病的作用作一综述. 趋向 随着研究的深入,必将全面地揭示PD1的病理生理意义、详细地阐明其效应机理,并最终研制出具有临床应用价值的新型抗炎药物.
揹景 保護素D1 (protectin D1,PD1)是近期髮現的由二十二碳六烯痠(docosahexenoic acid,DHA)衍生的生物活性分子,是機體一種重要的內源性脂質抗炎及促炎癥消退介質. 目的 深入認識這箇新的傢族有助于探討多種疾病的髮病機製,併為其治療提供新的靶點. 內容 大量研究錶明,PD1對多種炎性細胞的功能和多種炎癥相關基因的錶達有廣汎的調節作用,能促進炎癥反應及時消退,可改善多種疾病的轉歸.現就PD1的生物學活性、對炎性細胞及炎癥相關疾病的作用作一綜述. 趨嚮 隨著研究的深入,必將全麵地揭示PD1的病理生理意義、詳細地闡明其效應機理,併最終研製齣具有臨床應用價值的新型抗炎藥物.
배경 보호소D1 (protectin D1,PD1)시근기발현적유이십이탄륙희산(docosahexenoic acid,DHA)연생적생물활성분자,시궤체일충중요적내원성지질항염급촉염증소퇴개질. 목적 심입인식저개신적가족유조우탐토다충질병적발병궤제,병위기치료제공신적파점. 내용 대량연구표명,PD1대다충염성세포적공능화다충염증상관기인적표체유엄범적조절작용,능촉진염증반응급시소퇴,가개선다충질병적전귀.현취PD1적생물학활성、대염성세포급염증상관질병적작용작일종술. 추향 수착연구적심입,필장전면지게시PD1적병리생리의의、상세지천명기효응궤리,병최종연제출구유림상응용개치적신형항염약물.
Background Protectin D1 (PD1) is a new bioactive molecule derived from docosahexenoic acid (DHA),it is an important kind of endogenous lipid anti-inflammatory and pro-resolution medium.Objective Expanded understanding of PD1 contributes to investigate the pathogenesis of a variety of diseases and provide new targets for its treatment.Content Numerous studies suggest that PD1 can act on inflammatory cells and inflammatory-related genes,and improve the prognosis of many kinds of diseases,activate inflammation-resolution programmes.This review presents an update and overview of PD1 about its biological activity and its effects on inflammatory cells and inflammatory diseases.Trend With further research,it will fully reveal the pathophysiological significance of the PD1 and clarify the mechanism of its effects.It is thought that people will open up the clinical value of new anti-inflammatory drugs based on PD1.
