CAJ | 학술논문

目的探讨三维适形放疗同步紫杉醇+替吉奥方案化疗治疗进展期胃癌术后患者的临床疗效.方法将60例进展期胃癌术后患者按入院时间随机分为治疗组和对照组,每组30例.治疗组给予三维适形放疗同步紫杉醇+替吉奥方案化疗,对照组给予紫杉醇+替吉奥方案化疗.观察两组患者的远期生存率、局部复发率及不良反应.结果治疗组与对照组的1年生存率分别为93.1％(27/29)和72.4％(21/29),2年生存率分别为75.9％(22/29)和48.3％(14/29),治疗组与对照组的1年复发率分别为6.9％(2/29)和31.0％(9/29),2年复发率分别为13.8％(4/29)和44.8％(13/29),两组的1年和2年生存率、1年和2年复发率比较差异均有统计学意义(P＜ 0.05或＜0.01).两组不良反应主要表现为白细胞下降、血小板下降、贫血、恶心、呕吐、肝功能损害和口腔黏膜炎.其中治疗组恶心、呕吐的发生率明显高于对照组[83.3％(25/30)比53.3％(16/30)],差异有统计学意义(P=0.012).结论三维适形放疗同步紫杉醇+替吉奥方案化疗可提高进展期胃癌术后患者的远期生存率,降低局部复发率,但胃肠道不良反应有所增加.
목적 탐토삼유괄형방료동보자삼순+체길오방안화료치료진전기위암술후환자적림상료효.방법 장60례진전기위암술후환자안입원시간수궤분위치료조화대조조,매조30례.치료조급여삼유괄형방료동보자삼순+체길오방안화료,대조조급여자삼순+체길오방안화료.관찰량조환자적원기생존솔、국부복발솔급불량반응.결과 치료조여대조조적1년생존솔분별위93.1％(27/29)화72.4％(21/29),2년생존솔분별위75.9％(22/29)화48.3％(14/29),치료조여대조조적1년복발솔분별위6.9％(2/29)화31.0％(9/29),2년복발솔분별위13.8％(4/29)화44.8％(13/29),량조적1년화2년생존솔、1년화2년복발솔비교차이균유통계학의의(P＜ 0.05혹＜0.01).량조불량반응주요표현위백세포하강、혈소판하강、빈혈、악심、구토、간공능손해화구강점막염.기중치료조악심、구토적발생솔명현고우대조조[83.3％(25/30)비53.3％(16/30)],차이유통계학의의(P=0.012).결론 삼유괄형방료동보자삼순+체길오방안화료가제고진전기위암술후환자적원기생존솔,강저국부복발솔,단위장도불량반응유소증가.
Objective To investigate the clinical efficacy of postoperative three-dimensional conformal radiotherapy concurrent with paclitaxel +TS-1 chemotherapy in the treatment of advanced gastric carcinoma.Methods A total of 60 patients with advanced gastric carcinoma were randomly divided into treatment group and control group.In treatment group,30 patients received simultaneous three-dimensional conformal radiations therapy combined with paclitaxel +TS-1 chemotherapy.In control group,30 patients received paclitaxel +TS-1 chemotherapy.The long term survival rate,local recurrence rate and side reactions were observed in two groups.Results The 1,2-year survival rate in treatment group [93.1％ (27/29),75.9 ％ (22/29)] and control group [72.4 ％ (21/29),48.3 ％ (14/29)] had significant difference (P ＜ 0.05).The 1,2-year local recurrence rate in treatment group [6.9％ (2/29),13.8％ (4/29)] and control group [31.0％ (9/29),44.8 ％ (13/29)] had significant difference (P ＜ 0.05 or ＜ 0.01).The side reactions in two groups were mainly manifested as leukopenia,thrombocytopenia,anemia,nausea,vomiting,liver function damage and oral mucositis.The incidence rate of nausea,vomiting in treatment group was significantly higher than that in control group [83.3％ (25/30) vs.53.3％ (16/30)] (P =0.012).Conclusions Postoperative threedimensional conformal radiotherapy concurrent with paclitaxel +TS-1 chemotherapy in the treatment of advanced gastric carcinoma may improve the long-term survival rate,lower local recurrence rate.But the adverse reactions are increased.